Mephentermine

Mephentermine is a cardiac stimulant.

Mephentermine
Clinical data
Other namesmethyl(2-methyl-1-phenylpropan-2-yl)amine
Routes of
administration		IM/IV
ATC code
Pharmacokinetic data
MetabolismRapidly demethylated in the body followed by hydroxylation.
ExcretionVia urine (as unchanged and metabolites); more rapid in acidic urine.
Identifiers
IUPAC name
  • N,2-dimethyl-1-phenylpropan-2-amine
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.002.638
Chemical and physical data
FormulaC11H17N
Molar mass163.264 g·mol−1
3D model (JSmol)
SMILES
  • N(C(Cc1ccccc1)(C)C)C
InChI
  • InChI=1S/C11H17N/c1-11(2,12-3)9-10-7-5-4-6-8-10/h4-8,12H,9H2,1-3H3 Y
  • Key:RXQCGGRTAILOIN-UHFFFAOYSA-N Y
 NY (what is this?)  (verify)

It has been used as a treatment for low blood pressure.[1]

Mephentermine belongs to the class of adrenergic and dopaminergic cardiac stimulants excluding glycosides. Used in the treatment of heart failure.

Mechanism of action

Mephentermine appears to act by indirect stimulation of β-adrenergic receptors causing the release of norepinephrine from its storage sites. It has a positive inotropic effect on the myocardium. AV conduction and refractory period of AV node is shortened with an increase in ventricular conduction velocity. It dilates arteries and arterioles in the skeletal muscle and mesenteric vascular beds, leading to an increase in venous return.

Its onset is 5 to–15 minutes with intramuscular dosing, and immediate with intravenous dosing.

Its duration of action is four hours with intramuscular dosing and 30 minutes with intravenous dosing.

Indication and dosage

For maintenance of blood pressure in hypotensive states, the dose for adults is 30–45 mg as a single dose, repeated as necessary or followed by intravenous infusion of 0.1% mephentermine in 5% dextrose, with the rate and duration of administration depending on the patient's response.

For hypotension secondary to spinal anaesthesia in obstetric patients, the dose for adults is 15 mg as a single dose, repeated if needed. The maximum dose 30 mg.

Caution

Contraindications

Low blood pressure caused by phenothiazines, hypertension, and pheochromocytoma.

Special Precautions

Patients receiving monoamine oxidase inhibitors. For shock due to loss of blood or fluid, give fluid replacement therapy primarily, cardiovascular disease, hypertension, hyperthyroidism, chronic illnesses, lactation, pregnancy, skin dryness. headache.

Adverse Drug Reactions

The most common side effects are drowsiness, incoherence, hallucinations, convulsions, slow heart rate (reflex bradycardia). Fear, anxiety, restlessness, tremor, insomnia, confusion, irritability, and psychosis. Nausea, vomiting, reduced appetite, urinary retention, dyspnea, weakness, neck pain

Potentially fatal reactions are due to atrioventricular block, central nervous system stimulation, cerebral hemorrhage, pulmonary edema, and ventricular arrhythmias.

Drug Interactions

Mephentermine antagonizes effect of agents that lower blood pressure. Severe hypertension may occur with monoamine oxidase inhibitors and possibly tricyclic antidepressants. Additive vasoconstricting effects occur with ergot alkaloids, and oxytocin.

Potentially fatal drug interactions are the risk of abnormal heart rhythm in people undergoing anesthesia with cyclopropane and halothane.

References
  1. Whittington RM (May 1963). "Mephentermine Sulphate as a Hypertensive Agent in General Practice". The Journal of the College of General Practitioners. 6 (2): 336–7. PMC 1878111. PMID 14000433.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.