Clortermine

Clortermine (Voranil) was developed by Ciba in the 1960s[1] and is an anorectic drug of the amphetamine class.[2] It is the 2-chloro analogue of the better known appetite suppressant phentermine, and is the 2-chloro positional isomer of chlorphentermine. Clortermine produces very low rates of self-administration in animals similarly to chlorphentermine,[3] and as a result it likely does not act on dopamine. Instead, it may act as a serotonin and/or norepinephrine releasing agent.

Clortermine
Clinical data
Other names2-chloro-α,α-dimethylphenethylamine;
2-chloro-α-methylamphetamine;
2-chlorophentermine
Pregnancy
category
  •  ?
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • US: Schedule III
  • In general: ℞ (Prescription only)
Identifiers
IUPAC name
  • 1-(2-chlorophenyl)-2-methylpropan-2-amine
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC10H14ClN
Molar mass183.68 g·mol−1
3D model (JSmol)
SMILES
  • Clc1ccccc1CC(N)(C)C
InChI
  • InChI=1S/C10H14ClN/c1-10(2,12)7-8-5-3-4-6-9(8)11/h3-6H,7,12H2,1-2H3 Y
  • Key:HXCXASJHZQXCKK-UHFFFAOYSA-N Y
 NY (what is this?)  (verify)

See also

References
  1. US patent 3415937, "The Suppression of Appetite with 1-(o-Chlorophenyl)-2-Methyl-2-Propylamine"
  2. Triggle DJ (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall / CRC. ISBN 0-412-46630-9.
  3. Sannerud CA, Brady JV, Griffiths RR (1989). "Self-injection in baboons of amphetamines and related designer drugs". NIDA Research Monograph. 94: 30–42. PMID 2514366.
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