Isothipendyl

Isothipendyl is a 1st generation H1 antagonist (antihistamine) and anticholinergic used as an antipruritic.[1] It is nowadays scarcely used in the 1st line relief of allergies due to the anticholinergic side effect of somnolence but does have some limited use through topical application in the relief of insect bites and related itching (pruritus).

Isothipendyl
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
IUPAC name
  • N,N-dimethyl-1-(10H-pyrido[3,2-b][1,4]benzothiazin-10-yl)propan-2-amine
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.006.890
Chemical and physical data
FormulaC16H19N3S
Molar mass285.41 g·mol−1
3D model (JSmol)
SMILES
  • n2c1N(c3c(Sc1ccc2)cccc3)CC(N(C)C)C
InChI
  • InChI=1S/C16H19N3S/c1-12(18(2)3)11-19-13-7-4-5-8-14(13)20-15-9-6-10-17-16(15)19/h4-10,12H,11H2,1-3H3 Y
  • Key:OQJBSDFFQWMKBQ-UHFFFAOYSA-N Y
  (verify)

See also

References
  1. Bibas N, Sartor V, Bulai Livideanu C, Bagheri H, Nougué J, Giordano-Labadie F, et al. (2012). "Contact photoallergy to isothipendyl chlorhydrate". Dermatology. 224 (4): 289–291. doi:10.1159/000338024. PMID 22677929.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.