Pitrazepin

Pitrazepin is a competitive GABAA and glycine receptor antagonist.[1][2][3] It has been used to study insect and snail nervous systems in scientific research.[4][5][6][7][8][9]

Pitrazepin
Clinical data
Pregnancy
category
  •  ?
Routes of
administration		?
ATC code
  • none
Legal status
Legal status
  • In general: uncontrolled
Identifiers
IUPAC name
  • 3-(piperazin-1-yl)-9H-dibenzo[c,f][1,2,4]triazolo[4,3-a]azepine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H19N5
Molar mass317.396 g·mol−1
3D model (JSmol)
SMILES
  • n4nc(N1CCNCC1)n5c2ccccc2Cc3ccccc3c45

See also

References
  1. Gähwiler BH, Maurer R, Wüthrich HJ (April 1984). "Pitrazepin, a novel GABAA antagonist". Neuroscience Letters. 45 (3): 311–6. doi:10.1016/0304-3940(84)90244-1. PMID 6328380. S2CID 45153546.
  2. Braestrup C, Nielsen M (November 1985). "Interaction of pitrazepin with the GABA/benzodiazepine receptor complex and with glycine receptors". European Journal of Pharmacology. 118 (1–2): 115–21. doi:10.1016/0014-2999(85)90669-7. PMID 3002806.
  3. Curtis DR, Gynther BD (November 1986). "Pitrazepin: a central glycine and GABA antagonist". European Journal of Pharmacology. 131 (2–3): 311–3. doi:10.1016/0014-2999(86)90590-X. PMID 3816960.
  4. Anthony NM, Harrison JB, Sattelle DB (1993). "GABA receptor molecules of insects". Exs. 63: 172–209. doi:10.1007/978-3-0348-7265-2_8. ISBN 978-3-0348-7267-6. PMID 7678525.
  5. Sattelle DB, Pinnock RD, Wafford KA, David JA (January 1988). "GABA receptors on the cell-body membrane of an identified insect motor neuron". Proceedings of the Royal Society B. 232 (1269): 443–56. Bibcode:1988RSPSB.232..443S. doi:10.1098/rspb.1988.0006. PMID 2451252. S2CID 40290279.
  6. Murphy VF, Wann KT (November 1988). "The action of GABA receptor agonists and antagonists on muscle membrane conductance in Schistocerca gregaria". British Journal of Pharmacology. 95 (3): 713–22. doi:10.1111/j.1476-5381.1988.tb11697.x. PMC 1854212. PMID 2850061.
  7. Zhang W, Han XY, Wong SM, Takeuchi H (January 1997). "Pharmacologic characteristics of excitatory gamma-amino-butyric acid (GABA) receptors in a snail neuron". General Pharmacology. 28 (1): 45–53. doi:10.1016/S0306-3623(96)00152-8. PMID 9112076.
  8. Kim KH, Takeuchi H (June 1990). "Pharmacological characteristics of two different types of inhibitory GABA receptors on Achatina fulica neurones". European Journal of Pharmacology. 182 (1): 49–62. doi:10.1016/0014-2999(90)90492-O. PMID 2169426.
  9. Takeuchi H (September 1992). "Sensitivities of Achatina giant neurones to putative amino acid neurotransmitters". Comparative Biochemistry and Physiology C. 103 (1): 1–12. doi:10.1016/0742-8413(92)90219-w. PMID 1360362.


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