Nipecotic acid

Nipecotic acid
Identifiers
	IUPAC name Piperidine-3-carboxylic acid;
CAS Number	498-95-3;
PubChem CID	4498;
IUPHAR/BPS	4564;
ChemSpider	4342;
UNII	1U1QTN40SY;
ChEMBL	ChEMBL277498;
ECHA InfoCard	100.007.159
Chemical and physical data
Formula	C6H11NO2
Molar mass	129.159 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CC(CNC1)C(=O)O;

Nipecotic acid is a GABA uptake inhibitor[1] used in scientific research.[2][3]

References

Macdonald, R.L. (2012). Eadie, Mervyn J.; Vajda, Frank J. E. (eds.). Antiepileptic drugs: pharmacology and therapeutics (First ed.). [S.l.]: Springer. p. 130. ISBN 978-3-642-64244-9. In contrast, prolonged (1 h) exposure to gabapentin enhanced the shunting effect on CAl region excitatory postsynaptic potentials induced by the GABA uptake inhibitor, nipecotic acid, which promotes GABA release.
Takahashi K, Miyoshi S, Kaneko A, Copenhagen DR (1995). "Actions of nipecotic acid and SKF89976A on GABA transporter in cone-driven horizontal cells dissociated from the catfish retina". Jpn. J. Physiol. 45 (3): 457–73. doi:10.2170/jjphysiol.45.457. PMID 7474528.
Wahab A, Heinemann U, Albus K (October 2009). "Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures". Epilepsy Research. 86 (2–3): 113–23. doi:10.1016/j.eplepsyres.2009.05.008. PMID 19535226. S2CID 32999271.

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