Tolibut

Tolibut, also known as 3-(p-tolyl)-4-aminobutyric acid (or β-(4-methylphenyl)-GABA), is drug that was developed in Russia. It is an analogue of γ-aminobutyric acid (GABA) (that is, a GABA analogue) and is the 4-methyl analogue of phenibut, and is also an analogue of baclofen where the 4-chloro substitution has been replaced with a 4-methyl substitution. Tolibut has been described as possessing analgesic, tranquilizing, and neuroprotective properties. It is not fully clear as to whether the drug was ever approved or used medically in Russia, though it may have been.[1][2][3][4]

Tolibut
Clinical data
ATC code
  • None
Identifiers
IUPAC name
  • 4-Amino-3-(4-methylphenyl)butanoic acid
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC11H15NO2
Molar mass193.246 g·mol−1
3D model (JSmol)
SMILES
  • CC1=CC=C(C=C1)C(CC(=O)O)CN
InChI
  • InChI=1S/C11H15NO2/c1-8-2-4-9(5-3-8)10(7-12)6-11(13)14/h2-5,10H,6-7,12H2,1H3,(H,13,14)
  • Key:MSZRPURXKHMSFF-UHFFFAOYSA-N

See also

References
  1. Tyurenkov, I. N.; Borodkina, L. E.; Bagmetova, V. V. (2012). "Functional Aspects of Neuroprotective Effects of New Salts and Compositions of Baclofen in the Convulsive Syndrome Caused by Electroshock". Bulletin of Experimental Biology and Medicine. 153 (5): 710–713. doi:10.1007/s10517-012-1806-5. ISSN 0007-4888. PMID 23113265. S2CID 767044.
  2. I. S. Morozov, G. I. Kovalev, N. I. Maisov, G. V. Kovalev, K. S. Raevskii (January 1977). "Effect of analogs of γ -aminobutyric acid on the uptake of [3H]-γ -aminobutyric acid by synaptosomes of the rat brain". Pharmaceutical Chemistry Journal. 11 (1): 10–12. doi:10.1007/BF00779108. S2CID 27281385.{{cite journal}}: CS1 maint: uses authors parameter (link)
  3. Dmitriev AV, Andreev NIu (1987). "[The spectrum of analgesic activity of baclofen and tolibut]". Farmakol Toksikol (in Russian). 50 (1): 24–7. PMID 3556547.
  4. Artem'ev IIu, Darinskiĭ IuA, Sologub MI (1992). "[A hypothesis of the possible mechanism of the action of analgesic agents at the neuronal level]". Eksp Klin Farmakol (in Russian). 55 (1): 16–8. PMID 1363942.


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