Midaflur

Midaflur (INN; EXP 338) is an extremely stable 3-imidazoline derivative with central skeletal muscle relaxant and sedative properties in humans[1] and other species of mammals, exhibiting consistently high oral bioavailability and a long duration of action. While its pharmacodynamics remain poorly understood, midaflur resembles meprobamate and pentobarbital in terms of observed effects while being considerably more potent.[2]

Midaflur
Clinical data
ATC code
  • None
Identifiers
IUPAC name
  • 2,2,5,5-Tetrakis(trifluoromethyl)-2,5-dihydro-1H-imidazol-4-amine
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC7H3F12N3
Molar mass357.103 g·mol−1
3D model (JSmol)
SMILES
  • C1(=NC(NC1(C(F)(F)F)C(F)(F)F)(C(F)(F)F)C(F)(F)F)N
InChI
  • InChI=1S/C7H3F12N3/c8-4(9,10)2(5(11,12)13)1(20)21-3(22-2,6(14,15)16)7(17,18)19/h22H,(H2,20,21)
  • Key:KYWMWUUMCDZISK-UHFFFAOYSA-N

See also

References
  1. Levine IM, Jossmann PB, Friend DG, DeAngelis V (1967). "Effect of 5-imino-2,2,4,4-tetrakis (trifluoromethyl) imidazolidine (EXP 338) on spasticity: A quantitative evaluation". Clinical Pharmacology and Therapeutics. 9 (4): 448–55. doi:10.1002/cpt196894448. PMID 4871898. S2CID 39263140.
  2. Clark R, Lynes TE, Price WA, Smith DH, Woodward JK, Marvel JP, Vernier VG (April 1971). "The pharmacology and toxicology of midaflur". Toxicology and Applied Pharmacology. 18 (4): 917–43. doi:10.1016/0041-008x(71)90239-0. PMID 5570243.
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