List of polysubstance combinations

Polysubstance use refers to the use of combinations of psychoactive substances with both legal and illegal substances. This page lists polysubstance combinations used entheogenic, or recreational, or off-label indicated use of pharmaceuticals; For example, the over-the-counter motion sickness combination drug dimenhydrinate (8-chlorotheophylline/diphenhydramine) is occasially used in higher doses as a deliriant. The prescription medicine Adderall (dextroamphetamine sulfate/amphetamine sulfate/dextroamphetamine saccharate/amphetamine aspartate monohydrate) is also frequently used recreationally.

Drug 1 Drug 2 Drug 3 Polysubstance slang,[1][2][3] or brand name Intoxication name Comment
Any drug Black tar heroin Whoonga Widespread use in South Africa
Any drug Cannabis Amp joint[4]
Any drug Nicotine Cooler[5]
Any β-Carboline containing plant (e.g. Banisteriopsis caapi or Peganum harmala) DMT Ayahuasca, Changa Ayahuasca is drunk. Changa is smoked or vaped.
Any barbiturate Alcohol Used to be common, when Barbiturates were more readily available
Any deliriant, or diphenhydramine MDMA Nightmare flip Nightmare flipping
Any depressant Any stimulant Over and under
Any dissociative Any dissociative Void flip Void flipping
Any pharmaceutical Any pharmaceutical Polypharmacy Pharming Polypharmacy is most commonly defined as the use of five or more medications daily by an individual.[6] However, the definition of polypharmacy is still debated and can vary from two to 11 concurrent medications.[6]
2C-B LSD Banana split[4]
2C-B LSD MDMA Ali flip Ali flipping
2C-B MDMA Honey flip,[5] Nexus flip[7][8] Honey flipping, Nexus flipping The MDMA is often taken first and the 2C-B after the end of the MDMA peak.
2C-T-7 MDMA Lucky flip[5] Lucky flipping
8-chlorotheophylline Diphenhydramine Brand name: Dimenhydrinate. Slang terms: Drama, dime, dime tabs, D-Q, substance D, d-house, and drams.[9] Dramatizing or "going a dime a dozen"[10] Dimenhydrinate is recreationally used as a deliriant.[11][12][13]
Alcohol Benzodiazepine Time flip Time flipping
Alcohol Caffeine Caffeinated alcoholic drink
Alcohol Cannabis Tincture of cannabis. Herb and Al. Judgement Day Cross fading Called Judgement Day in Ghana when cannabis is added to the drink
Alcohol Cocaine Snow-cone Snow-coning Ethanol is metabolized into cocaethylene[14]
Alcohol MDMA Tipsy flip Tipsy flipping
Alcohol Nicotine Nicotini A nicotini is any alcoholic drink which includes nicotine as an ingredient. Nicotine replacement therapy products such as mouth spray may be used.
Amphetamine Barbiturates Inbetweens[15]
Amphetamine Cannabis LSD Hippie heart attack
Amphetamine Cocaine Snow seals
Amphetamine Heroin Bombido[15]
Amphetamine Xanax Orange Dream Blossom Cloud Rush The combination is crushed together and insufflated
Belladonna Hashish Alamout black hash[5] Mixed
Caffeine Cannabis Hippie-speedball Hippie-speedballing
Caffeine Diphenhydramine Sleep walk Sleepwalking
Caffeine Methamphetamine Ya ba, biker's coffee, kamikaze
Cacao bean Magic mushroom Aztec use of entheogens. Conventional defatted cocoa solids dissolved in fat may be used instead of whole beans.
CBD THC CBD might counteract some of the paranoia, anxiety,[16] and reduction of hippocampal volumes that the current high potency THC marijuana (in the last decades, THC content increased and CBD content decreased) can cause.[17][18]
Cannabis Cocoa solids Cannabis-infused brownie Cannabis edible
Cannabis Crack cocaine Crack weed (less known: champagne, chronic, cocktail, dirty joint, fry daddy, gimmie, gremmies, juice joint, lace, oolies, p dog, primo, thirty eight, turbo, wollie, yeola) Cocoa puffs, splitting
Cannabis Crack cocaine Heroin Major Pronin
Cannabis Crack cocaine PCP Jim Jones
Cannabis Damiana Damiana and other herbs can be used as a tobacco alternative for rolling joints.[19]
Cannabis DXM Nicotine Candy blunt
Cannabis Heroin or opium A-bomb, Atom bomb, stuff[5]
Cannabis MDMA Stoner flip Stoner flipping
Cannabis Nicotine Blunt, joint, spliff A rolled cannabis cigarette usually made with rolling paper. A blunt is a cigar hollowed out and filled with cannabis. It is rolled with the tobacco-leaf "wrapper" from an inexpensive cigar. Blunts take their name from Phillies Blunt brand cigars.
Cannabis Opium Buddha
Cannabis PCP Wet (less known: Bionic, clickums, donk, illies, leak, love leaf, lovelies, parsley, supergrass, superweed, wet, zoom) Illing Wet is cannabis dipped in PCP [20]
Cannabis PCP Nicotine Wet blunt, dust blunt, dusted blunt, Kendrick Lamar blunt Illing
Cocaine Heroin or morphine Powerball, speedball Powerballing, speedballing[5] Speedballing, powerballing is often used to describe intravenous use. The term can also be applied to use of pharmaceutical opioids, benzodiazepines or barbiturates along with stimulants.
Cocaine Heroin Snowball. Other names: Belushi, bombita, murder one, whiz bang Snowballing
Cocaine Heroin LSD Frisco special[5]
Cocaine Heroin Nicotine Flamethrower, primos Cigarette laced with cocaine and heroin
Cocaine Ketamine CK1, Calvin Klein, cable
Cocaine Ketamine MDMA Ketamollicaine
Cocaine LSD MDMA Candy-flip on a string Candy-flipping on a string
Cocaine MDMA Sugar flip Sugar flipping
Cocaine Morphine C & M
Cocaine PCP Space, whack
Cocaine Wine Coca wine Ethanol is metabolized into cocaethylene
Cocaine Quetiapine Q-ball
Codeine Glutethimide Pancakes and syrups Combination of glutethimide and codeine cough syrup
Codeine Promethazine Lean, purple drank, oil
Crack cocaine Fentanyl Dirty fentanyl, takeover
Crack cocaine Heroin Chocolate rock, dragon rock, eightball, moonrock, smoking gun, tar
Crack cocaine LSD Cracid, outerlimits Cracid is a portmanteau of crack cocaine and acid
Crack cocaine Methamphetamine Fire, twisters
Crack cocaine Nicotine Coolie, crimmie, woolas A cigarette laced with crack
Crack cocaine Nicotine PCP Ozone PCP and crack cigarette
Crack cocaine PCP Missile base, P-funk, space base, spaceball, space cadet, space dust, tragic magic Missile basing, space basing
Diphenhydramine DXM OTC flip OTC flipping, robowalking on a string
DMT LSD Cosmo flip Cosmo flipping
DMT LSD Psilocybin or psilocybin mushroom Super flip Super flipping Take LSD and shrooms then at the come up smoke DMT
DMT MAOIs Pharmahuasca
DMT Psilocybin or psilocybin mushroom Terence flip Terence flipping
DXM LSD LSDXM
DXM MDMA Robo flip Robo flipping
DXM Psilocybin or psilocybin mushroom Cherry-bomb Cherry-bombing
Fentanyl Heroin Birria, chiva loca, Facebook Facebook is mixed in a pill form
GHB MDMA Gamma flip Gamma flipping
GHB Methamphetamine Cherry meth
Hashish LSD Royal temple ball The hashish is mixed with LSD and rolled into a ball intended for oral use, because LSD cannot be smoked.
Hashish Opium Black hash, black Russian
Heroin Methamphetamine Goofball
Heroin Morphine New Jack swing
Heroin PCP Alien sex fiend[5]
Ketamine LSD Dolphin flip Dolphin flipping
Ketamine MDMA Kitty flip[7] Kitty flipping
LSD Ketamine MDMA Holy Trident Holy Tridenting
LSD MDMA Candy flip Candy flipping[5]
LSD MDMA Psilocybin or psilocybin mushroom Jedi flip,[7] twilight flip Jedi flipping, twilight flipping
LSD Mescaline Sunny trip
LSD Nitrous oxide Gasid
LSD PCP Black acid
LSD Psilocybin or psilocybin mushroom God's flesh, Soul Bomb, Alice[5]
MDMA Mescaline or psychoactive cactus Love flip, love trip Love flipping
MDMA Methadone Chocolate flip Chocolate flipping
MDMA Methamphetamine Trailer flip Trailer flipping
MDMA DMT Shaman flip, time flip Shaman flipping, time flipping
MDMA Nitrous oxide Nox
MDMA Opiates Poppy flip Poppy flipping
MDMA PCP Domex, elephant flip Elephant flipping
MDMA Psilocybin or psilocybin mushroom Hippy flip[7] Hippy flipping[21]
MDMA Xanax Zen flip Zen flipping
Nicotine PCP Chipping, fry cigarette
Pentazocine Tripelannamine T's and blues
Venlafaxine Mirtazepine California rocket fuel

A drug combination chart designed for harm reduction.

See also
  • List of plants used for smoking

References
  1. "Erowid Drug Slang & Terminology Vault : A - B". erowid.org.
  2. Copping, Jasper (8 November 2009). "Drug slang: what police must learn A to B".
  3. https://ndews.umd.edu/sites/ndews.umd.edu/files/dea-drug-slang-terms-and-code-words-july2018.pdf
  4. "Slang Terms for Drug Combinations". Narconon International. Retrieved 2021-12-08.
  5. "Erowid Drug Slang & Terminology Vault : A - B". erowid.org.
  6. Masnoon, Nashwa; Shakib, Sepehr; Kalisch-Ellett, Lisa; Caughey, Gillian E. (October 2017). "What is polypharmacy? A systematic review of definitions". BMC Geriatrics. 17 (1): 230. doi:10.1186/s12877-017-0621-2. ISSN 1471-2318. PMC 5635569. PMID 29017448.
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  8. "What is 2C-B? The Complete and Honest Explainer". Double Blind. 26 June 2020. Retrieved 16 July 2020.
  9. "The Dangers of Dimenhydrinate Abuse". Bright Hub. 2009-10-06. Retrieved 2016-09-13.
  10. "Dramamine". Budderbongs forums. Retrieved 2016-09-13.
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  13. Gardner DM, Kutcher S (March 1993). "Dimenhydrinate abuse among adolescents". Canadian Journal of Psychiatry. 38 (2): 113–6. doi:10.1177/070674379303800208. PMID 8467436. S2CID 30190588.
  14. Pergolizzi, Joseph; Breve, Frank; Magnusson, Peter; LeQuang, Jo Ann K.; Varrassi, Giustino (2022-02-22). "Cocaethylene: When Cocaine and Alcohol Are Taken Together". Cureus. 14 (2). doi:10.7759/cureus.22498. ISSN 2168-8184.
  15. Keup, Wolfram (June 1971). "The Vocabulary of the Drug User and Alcoholic: A Glossary". The International Journal of the Addictions. 6 (2): 348. doi:10.3109/10826087109057793. PMID 4950517. Retrieved 7 October 2021.
  16. Gibson LP, Karoly HC, Ellingson JM, Klawitter J, Sempio C, Squeri JE, Bryan AD, Bidwell LC, Hutchison KE. (2022). "Effects of cannabidiol in cannabis flower: Implications for harm reduction". Addiction Biology. 27 (1): e13092. doi:10.1111/adb.13092. PMID 34467598. S2CID 237372495.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  17. Stuyt, Elizabeth (2018). "The Problem with the Current High Potency THC Marijuana from the Perspective of an Addiction Psychiatrist". Missouri Medicine. 115 (6): 482–486. ISSN 0026-6620. PMC 6312155. PMID 30643324.
  18. ElSohly, Mahmoud A.; Mehmedic, Zlatko; Foster, Susan; Gon, Chandrani; Chandra, Suman; Church, James C. (2016-04-01). "Changes in Cannabis Potency over the Last Two Decades (1995-2014) - Analysis of Current Data in the United States". Biological Psychiatry. 79 (7): 613–619. doi:10.1016/j.biopsych.2016.01.004. ISSN 0006-3223. PMC 4987131. PMID 26903403.
  19. Ewe, Koh (2021-04-19). "TikTokers Are Smoking Flowers As Weed Alternatives". www.vice.com. Retrieved 2021-12-24.{{cite web}}: CS1 maint: url-status (link)
  20. Holland, Julie A.; Nelson, Lewis; Ravikumar, P. R.; Elwood, William N. (22 February 2017). "Embalming Fluid-Soaked Marijuana: New High or New Guise for PCP?". Journal of Psychoactive Drugs. 30 (2): 215–219. doi:10.1080/02791072.1998.10399693. PMID 9692385. Retrieved 30 July 2021 – via Erowid.org.
  21. Dalzell, Tom; Victor, Terry (2008). Vice Slang. Routledge. p. 91. ISBN 978-0415371810.
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