Rubidium-82 chloride

Rubidium-82 chloride is a form of rubidium chloride containing a radioactive isotope of rubidium. It is marketed under the brand name Cardiogen-82 by Bracco Diagnostics for use in Myocardial perfusion imaging.[1] It is rapidly taken up by heart muscle cells, and therefore can be used to identify regions of heart muscle that are receiving poor blood flow in a technique called PET perfusion imaging.[2] The half-life of the rubidium-82 is only 1.27 minutes; it is normally produced at the place of use by rubidium generators.[3]

Rubidium-82 chloride
Names
IUPAC name
Rubidium-82 chloride
Systematic IUPAC name
(82Rb)Rubidium chloride
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
KEGG
PubChem CID
UNII
InChI
  • InChI=1S/ClH.Rb/h1H;/q;+1/p-1/i;1-3 Y
    Key: FGDZQCVHDSGLHJ-RYDPDVNUSA-M Y
SMILES
  • [Cl-].[82Rb+]
Properties
Chemical formula
 ClRb
Molar mass 117.371 g mol−1
Pharmacology
V09GX04 (WHO)
Related compounds
Other cations
 Caesium chloride

Lithium chloride
Potassium chloride
Rubidium chloride
Sodium chloride

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

References
  1. Wackers, Frans J. Th.; Bruni, Wendy; Zaret, Barry L. (2007-11-19). "Rubidium-82 Generator". Nuclear cardiology: the basics: how to set up and maintain a laboratory. ISBN 978-1-58829-924-6.
  2. Ballinger, James R. (2009). "PET Radiopharmaceuticals in Nuclear Cardiology: Current Status and Limitations". Integrating Cardiology for Nuclear Medicine Physicians. pp. 379–385. doi:10.1007/978-3-540-78674-0_32. ISBN 978-3-540-78673-3.
  3. Gould, K. Lance; Goldstein, Richard A.; Mullani, Nizar A.; Kirkeeide, Richard L.; Wong, Wai-Hoi; Tewson, Timothy J.; Berridge, Marc S.; Bolomey, Leonard A.; Hartz, Ross K.; Smalling, Richard W.; Fuentes, Francisco; Nishikawa, Akira (1986). "Noninvasive assessment of coronary stenoses by myocardial perfusion imaging during pharmacologic coronary vasodilation. VIII. Clinical feasibility of positron cardiac imaging without a cyclotron using generator-produced Rubidium-82". Journal of the American College of Cardiology. 7 (4): 775–789. doi:10.1016/S0735-1097(86)80336-9. PMID 3485669.

Further reading
  • Clarke, Michael J; Sadler, P. J (1999-06-15). Metallopharmaceuticals: Diagnosis and therapy. ISBN 978-3-540-65308-0. (Note: only about 1/2 page on Rb-generator)
  • Alvarez-Diez, T; Dekemp, R; Beanlands, R; Vincent, J (1999). "Manufacture of strontium-82/rubidium-82 generators and quality control of rubidium-82 chloride for myocardial perfusion imaging in patients using positron emission tomography". Applied Radiation and Isotopes. 50 (6): 1015–23. doi:10.1016/S0969-8043(98)00170-5. PMID 10355104.
  • Waters, S. L.; Coursey, B. M., eds. (1987). "The Strontium-82/rubidium-82 generator". International Journal of Radiation Applications and Instrumentation A. 38 (3): 171–239.


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