Thienopyridine

Thienopyridines are a class of selective, reversible[1] ADP receptor/P2Y12 inhibitors used for their anti-platelet activity.

Ticlopidine
Clopidogrel
Prasugrel

Examples

Drugs in this class include: clopidogrel (Plavix),[2] prasugrel (Effient),[3] and ticlopidine (Ticlid).

Tinoridine was actually a predecessor to this work.

Alternatives

Ticagrelor (Brilinta) is often listed with thienopyridine inhibitors and has similar indications for use but is not a thienopyridine. It is a cyclo-pentyltriazolo-pyrimidine that reversibly inhibits the P2Y12 receptor.[1]

References
  1. Alexopoulos, Dimitrios (2014). "P2Y12 Receptor Inhibitors in Acute Coronary Syndromes: From the Research Laboratory to the Clinic and Vice Versa". Cardiology. 127 (4): 211–219. doi:10.1159/000357399. PMID 24458006.
  2. Depta, Jeremiah P.; Bhatt, Deepak L. (2008-01-01). "Aspirin and platelet adenosine diphosphate receptor antagonists in acute coronary syndromes and percutaneous coronary intervention: role in therapy and strategies to overcome resistance". American Journal of Cardiovascular Drugs. 8 (2): 91–112. doi:10.1007/BF03256587. ISSN 1175-3277. PMID 18422393.
  3. Angiolillo DJ, Bates ER, Bass TA (August 2008). "Clinical profile of prasugrel, a novel thienopyridine". Am. Heart J. 156 (2 Suppl): S16–22. doi:10.1016/j.ahj.2008.06.005. PMID 18657682.


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