Aloxiprin

Aloxiprin (or aluminium acetylsalicylate) is a medical drug used for the treatment of pain and inflammation associated with muscular skeletal and joint disorders.[1] It is used for its properties as an anti-inflammatory, antipyretic and analgesic drug.[1] It is a chemical compound of aluminium hydroxide and aspirin.[2][3]

Aloxiprin
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
IUPAC name
  • aluminum 2-acetyloxybenzoate hydroxide
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.041.481
Chemical and physical data
FormulaC18H15AlO9
Molar mass402.288 g·mol−1
3D model (JSmol)
SMILES
  • [Al+3].O=C(Oc1ccccc1C([O-])=O)C.[OH-].[O-]C(=O)c1ccccc1OC(=O)C

  • CC(=O)Oc0ccccc0C(=O)O[Al](O)OC(=O)c1ccccc1OC(=O)C
InChI
  • InChI=1S/2C9H8O4.Al.H2O/c2*1-6(10)13-8-5-3-2-4-7(8)9(11)12;;/h2*2-5H,1H3,(H,11,12);;1H2/q;;+3;/p-3 Y
  • Key:MANKSFVECICGLK-UHFFFAOYSA-K Y
  (verify)

Alternative names and combinations
  • Palaprin Forte.[4]
  • Askit Powders - A powder combination of aspirin, aloxiprin and caffeine.[5]

Contraindications
  • People with allergies to salicylates.
  • People with gastrointestinal ulcers.
  • People with liver or kidney damage.
  • Pregnant women in the 3rd trimester.
  • Women who are breastfeeding.
  • Use with other salicylates.
  • Use with NSAIDs.

References
  1. MIMS. "Aloxiprin". MIMS. Retrieved 16 April 2011.
  2. Encarta. "Aloxiprin". Encarta. Retrieved 16 April 2011.
  3. CUMMINGS AJ, MARTIN BK, WIGGINS LF (1963). "In vitro and in vivo properties of aloxiprin: a new aluminium derivative of acetylsalicylic acid". J. Pharm. Pharmacol. 15: 56–62. doi:10.1111/j.2042-7158.1963.tb12743.x. PMID 14024235. S2CID 33366977.
  4. Geller J (1968). "A comparative trial of aloxiprin ('Palaprin Forte') and phenylbutazone ('Butazolidin')". The British Journal of Clinical Practice. 22 (9): 392–4. PMID 4876729.
  5. Net Doctor UK. "Askit Powders". Treatments for joint, muscle and bone conditions. Retrieved 16 April 2011.


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