Tilmacoxib

Tilmacoxib or JTE-522 is a COX-2 inhibitor and is an effective chemopreventive agent against rat experimental liver fibrosis.[1]

Tilmacoxib
Pharmacokinetic data
Bioavailabilitysolution (64–88%) compared with capsule (22–40%).
Identifiers
IUPAC name
  • 4-(4-cyclohexyl-2-methyl-1,3-oxazol-5-yl)-2-fluorobenzenesulfonamide
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H19FN2O3S
Molar mass338.40 g·mol−1
3D model (JSmol)
SMILES
  • O=S(=O)(N)c3ccc(c1oc(nc1C2CCCCC2)C)cc3F
InChI
  • InChI=1S/C16H19FN2O3S/c1-10-19-15(11-5-3-2-4-6-11)16(22-10)12-7-8-14(13(17)9-12)23(18,20)21/h7-9,11H,2-6H2,1H3,(H2,18,20,21)
  • Key:MIMJSJSRRDZIPW-UHFFFAOYSA-N

See also

References
  1. Yamamoto H, Kondo M, Nakamori S, Nagano H, Wakasa K, Sugita Y, et al. (August 2003). "JTE-522, a cyclooxygenase-2 inhibitor, is an effective chemopreventive agent against rat experimental liver fibrosis1". Gastroenterology. 125 (2): 556–71. doi:10.1016/s0016-5085(03)00904-1. PMID 12891558.
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