Etofenamate

Etofenamate is a nonsteroidal anti-inflammatory drug (NSAID) used for the treatment of joint and muscular pain.[1] It is available for topical application as a cream, a gel or as a spray.

Etofenamate
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Topical (cream, gel, spray)
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding98–99%
MetabolitesFlufenamic acid, hydroxyl derivatives
Excretion35% renal, mostly biliary
Identifiers
IUPAC name
  • 2-(2-hydroxyethoxy)ethyl 2-[ [3-(trifluoromethyl)phenyl]amino]benzoate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.045.650
Chemical and physical data
FormulaC18H18F3NO4
Molar mass369.340 g·mol−1
3D model (JSmol)
SMILES
  • FC(F)(F)c1cc(ccc1)Nc2ccccc2C(=O)OCCOCCO
InChI
  • InChI=1S/C18H18F3NO4/c19-18(20,21)13-4-3-5-14(12-13)22-16-7-2-1-6-15(16)17(24)26-11-10-25-9-8-23/h1-7,12,22-23H,8-11H2 Y
  • Key:XILVEPYQJIOVNB-UHFFFAOYSA-N Y
  (verify)

Etofenamate is acutely toxic if swallowed; it is also very toxic to aquatic life, with long lasting effects.[2]

References
  1. Chlud K (1999). "[Use of topical non-steroidal anti-inflammatory drugs in aggravated and decompensated arthroses]". Wiener Medizinische Wochenschrift (in German). 149 (19–20): 546–7. PMID 10637963.
  2. "Etofenamate". PubChem.
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