Bendazac

Bendazac (or bendazolic acid) is a nonsteroidal anti-inflammatory drug (NSAID) used for joint and muscular pain.[1]

Bendazac
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Topical
ATC code
Identifiers
IUPAC name
  • [(1-benzyl-1H-indazol-3-yl)oxy]acetic acid
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.039.594
Chemical and physical data
FormulaC16H14N2O3
Molar mass282.299 g·mol−1
3D model (JSmol)
SMILES
  • O=C(O)COc2nn(c1ccccc12)Cc3ccccc3
InChI
  • InChI=1S/C16H14N2O3/c19-15(20)11-21-16-13-8-4-5-9-14(13)18(17-16)10-12-6-2-1-3-7-12/h1-9H,10-11H2,(H,19,20) Y
  • Key:BYFMCKSPFYVMOU-UHFFFAOYSA-N Y
 NY (what is this?)  (verify)

Synthesis

Principal action is inhibition of protein denaturation.

Bendazac synthesis: BE 699226; G. Palazzo, U.S. Patent 3,470,194 (1967, 1969 both to Francesco Angelini).

Use of chloroacetamide in the alkylation step, followed by acid hydrolysis produces bendazac (instead of benzydamine).

See also

References
  1. Balfour JA, Clissold SP (April 1990). "Bendazac lysine. A review of its pharmacological properties and therapeutic potential in the management of cataracts". Drugs. 39 (4): 575–96. doi:10.2165/00003495-199039040-00007. PMID 2190795. S2CID 46956362.



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