Oxaceprol

Oxaceprol is an anti-inflammatory drug used in the treatment of osteoarthritis.[1] It is derived from L-proline, a DNA-encoded amino acid. The active effect of Oxaceprol is to inhibit the adhesion and migration of white blood cells.[2]

Oxaceprol
Clinical data
Other names(2S,4R)-1-acetyl-4-hydroxypyrrolidine-2-carboxylic acid
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
IUPAC name
  • (4R)-1-acetyl-4-hydroxy-L-proline
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.047.058
Chemical and physical data
FormulaC7H11NO4
Molar mass173.168 g·mol−1
3D model (JSmol)
SMILES
  • CC(=O)N1C[C@@H](C[C@H]1C(=O)O)O
InChI
  • InChI=1S/C7H11NO4/c1-4(9)8-3-5(10)2-6(8)7(11)12/h5-6,10H,2-3H2,1H3,(H,11,12)/t5-,6+/m1/s1
  • Key:BAPRUDZDYCKSOQ-RITPCOANSA-N
  (verify)

References
  1. Herrmann G, Steeger D, Klasser M, Wirbitzky J, Fürst M, Venbrocks R, et al. (2000). "Oxaceprol is a well-tolerated therapy for osteoarthritis with efficacy equivalent to diclofenac". Clinical Rheumatology. 19 (2): 99–104. doi:10.1007/s100670050025. PMID 10791619. S2CID 25654850.
  2. Clayton JJ (August 2007). "Nutraceuticals in the management of osteoarthritis". Orthopedics. 30 (8): 624–9, quiz 630-1. doi:10.3928/01477447-20070801-13. PMID 17727018. Retrieved 2013-06-08.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.