Plasmodium ovale

Plasmodium ovale
Plasmodium ovale trophozoite, Giemsa stain.
Scientific classification edit
Domain: Eukaryota
Clade: Diaphoretickes
Clade: TSAR
Clade: SAR
Clade: Alveolata
Phylum: Apicomplexa
Class: Aconoidasida
Order: Haemospororida
Family: Plasmodiidae
Genus: Plasmodium
Species:
P. ovale
Binomial name
Plasmodium ovale
Stephens, 1922

Plasmodium ovale is a species of parasitic protozoon that causes tertian malaria in humans. It is one of several species of Plasmodium parasites that infect humans, including Plasmodium falciparum and Plasmodium vivax which are responsible for most cases of malaria in the world. P. ovale is rare compared to these two parasites, and substantially less dangerous than P. falciparum.

P. ovale has recently been shown by genetic methods to consist of what is considered to be two species (despite having been given subspecies names), namely P. ovale curtisi and P. ovale wallikeri.[1]

Life cycle

P. ovale is introduced into the human host by the bite of an infected mosquito, in a motile form called a sporozoite. The sporozoites are carried by the blood to the liver, where they replicate asexually by merogony into non-motile merozoites. Several hundred merozoites are produced and released into the bloodstream where they infect erythrocytes. Inside the erythrocyte, the parasite's replication cycle takes approximately 49 hours, after which the erythrocyte ruptures and between 8 and 20 merozoites are released to infect other erythrocytes. Some of these merozoites will instead form gametocytes which remain in the blood and are ingested by a mosquito.[2]

When gametocytes are ingested by a mosquito, the gametocytes enter the mosquito gut where fertilisation occurs forming a zygote known as an ookinete. The ookinete moves to the outer wall of the mosquito midgut where it develops over the course of several weeks. This developing stage is called an oocyst. After the oocyst develops, it ruptures releasing several hundred sporozoites. The sporozoites are carried by the mosquito's circulation to the mosquito salivary glands. When the mosquito feeds again, the sporozoites enter through the salivary duct and are injected into a new host, starting the life cycle again.[2]

There are situations where some of the sporozoites hypothetically do not immediately start to grow and divide after entering the hepatocyte, but remain in a dormant, hypnozoite stage[3] for weeks or months. However, unlike the P. vivax situation, hypnozoites have yet to actually be seen in the life cycle of P. ovale.[4] The duration of latency is variable from one (assumed in the case of P. ovale) hypnozoite to another and the factors that will eventually trigger growth are not known; this could explain how a single infection can be responsible for a series of waves of parasitaemia or "relapses".[5]

  • Giemsa-stained microscopy of Plasmodium ovale
    Giemsa-stained microscopy of Plasmodium ovale
  • Microphotographs of Plasmodium ovale in Giemsa-stained thin blood films. a–c ring stages, d, e young trophozoites, f trophozoite, g late trophozoite, h young schizont, i–k growing schizont, l late schizont, m ruptured schizont, n young gametocyte, o, p developing macrogametocytes, q macrogametocyte, r microgametocyte.
    Microphotographs of Plasmodium ovale in Giemsa-stained thin blood films. a–c ring stages, d, e young trophozoites, f trophozoite, g late trophozoite, h young schizont, i–k growing schizont, l late schizont, m ruptured schizont, n young gametocyte, o, p developing macrogametocytes, q macrogametocyte, r microgametocyte.[6]

Phylogenetics

Among the species infecting the great apes, Plasmodium schwetzi morphologically appears to be the closest relation to P.ovale. As of 2013 this had not been confirmed by DNA studies.

The original species has been shown to be two morphologically identical forms – Plasmodium ovale curtisi and Plasmodium ovale wallikeri – which can be differentiated only by genetic means.[1] Both species have been identified in Ghana, Myanmar, Nigeria, São Tomé, Sierra Leone and Uganda. The separation of the lineages is estimated to have occurred between 1.0 and 3.5 million years ago in hominid hosts. A second analysis suggests that these species separated 4.5 million years ago (95% confidence interval 0.5 – 7.7 Mya).[7] A third worked sequenced the whole genome of both species, confirmed the differences and dated the split at around million years.[8] Although dating is always difficult, the authors date that split to be 5 times older than the P. falciparum and P. reichenowi split.

These species appear to be more closely related to Plasmodium malariae than to Plasmodium vivax.[7]

The two species appear to differ biologically, with P. ovale wallikeri having a shorter latency period than P. ovale curtisi.[9]

Epidemiology

Relative incidence of Plasmodium species by country of origin for imported cases to non-endemic countries, showing P. ovale in pink.[10]

P. ovale is primarily concentrated in sub-Saharan Africa and islands in the western Pacific.[2][11] However P. ovale has also been reported in the Philippines, eastern Indonesia, and Papua New Guinea,[12] as well as in Bangladesh,[13] Cambodia,[14] India,[15] Myanmar,[16] Thailand[17] and Vietnam[18]

In several studies, the reported prevalence of P. ovale was low relative to other malaria parasites, with fewer than 5% of malaria cases being associated with P. ovale infection. Higher prevalences of P. ovale are possible under certain conditions, as at least one study in Cameroon found the prevalence of P. ovale infection to be greater than 10%.[2]

It has been estimated that there are about 15 million cases of infection each year with this parasite.[1]

While similar to P. vivax, P. ovale is able to infect individuals who are negative for the Duffy blood group, which is the case for many residents of sub-Saharan Africa. This has been said to explain the greater prevalence of P. ovale (versus P. vivax) in most of Africa. [19] However, low-parasitaemia or subpatent P. vivax cases might be more prevalent in Africa than has been thought.[20]

Human disease

In humans, symptoms generally appear 12 to 20 days after the parasite has entered the blood. In the blood, the parasite's replication cycle lasts approximately 49 hours, causing tertian fever which spikes approximately every 49 hours as newly replicated parasites erupt out of red blood cells. Mean maximum parasite levels have been found to be 6,944/microl for sporozoite-induced infections and 7,310/microl for trophozoite-induced infections.[2]

In some cases, relapse may occur up to 4 years after infection.[2]

Diagnosis

Plasmodium ovale microgametocyte in Giemsa-stained thin blood film, with annotated Schüffner's dots and hemozoin pigment.

The microscopic appearance of P. ovale is very similar to that of P. vivax and if there are only a small number of parasites seen, it may be impossible to distinguish the two species on morphological grounds alone. There is no difference between the medical treatment of P. ovale and P. vivax, and therefore some laboratory diagnoses report "P. vivax/ovale", which is perfectly acceptable as treatment for the two is very similar. Schüffner's dots are seen on the surface of the parasitised red blood cell, but these are larger and darker than in P. vivax and are sometimes called James' dots or James' stippling. About twenty percent of the parasitised cells are oval in shape (hence the species name) and some of the oval cells also have fimbriated edges (the so-called "comet cell"). The mature schizonts of P. ovale never have more than twelve nuclei within them and this is the only reliable way of distinguishing between the two species.

P. vivax and P. ovale that have been sitting in EDTA for more than half an hour before the blood film is made will look very similar in appearance to P. malariae, which is an important reason to warn the laboratory immediately when the blood sample is drawn so they can process the sample as soon as it arrives.

Molecular tests (tests that detect DNA in blood) must take into account the fact that there are two P. ovale sensu lato taxa. Tests designed for one will not necessarily detect the other.[21]

Treatment

Standard treatment is concurrent treatment with chloroquine and primaquine. The combination atovaquone-proguanil may be used in those patients who are unable to take chloroquine for whatever reason.[22] An overdose on Chloroquine can be very dangerous and can result in death.

Hosts

While humans appear to be the natural mammalian host of P. ovale, chimpanzees and Saimiri monkeys have also been experimentally infected.[2]

Anopheles gambiae and Anopheles funestus are likely the natural mosquito hosts of P. ovale. Experimentally, several other mosquito species have been shown to be capable of transmitting P. ovale to humans, including:

  • Anopheles albimanus
  • Anopheles atroparvus
  • Anopheles dirus
  • Anopheles farauti
  • Anopheles freeborni
  • Anopheles maculatus
  • Anopheles quadrimaculatus
  • Anopheles stephensi
  • Anopheles subpictus[2]

Genomes

The full genomes of the two P. ovale species can be seen on geneDB.org – P. ovali curtisi Archived 2016-10-09 at the Wayback Machine P. ovale wallikeri Archived 2023-07-01 at the Wayback Machine and plasmoDB.org Archived 2023-03-28 at the Wayback Machine, published 2017.[8]

History

This species was first described in 1914 by Stephens in a blood sample taken in the autumn of 1913 from a patient in the sanitarium of Pachmari in central India and sent by Major W. H. Kenrick to Stephens (who was working in Liverpool).[23]

See also

References

  1. 1 2 3 Sutherland CJ, Tanomsing N, Nolder D, Oguike M, Jennison C, Pukrittayakamee S, et al. (May 2010). "Two nonrecombining sympatric forms of the human malaria parasite Plasmodium ovale occur globally". The Journal of Infectious Diseases. 201 (10): 1544–50. doi:10.1086/652240. PMID 20380562.
  2. 1 2 3 4 5 6 7 8 Collins WE, Jeffery GM (July 2005). "Plasmodium ovale: parasite and disease". Clinical Microbiology Reviews. 18 (3): 570–81. doi:10.1128/CMR.18.3.570-581.2005. PMC 1195966. PMID 16020691.
  3. ↑ Markus MB (2011). "Malaria: origin of the term "hypnozoite"". Journal of the History of Biology. 44 (4): 781–6. doi:10.1007/s10739-010-9239-3. PMID 20665090. S2CID 1727294.
  4. ↑ Markus, MB (2021). "Safety and efficacy of tafenoquine for Plasmodium vivax malaria prophylaxis and radical cure: overview and perspectives". Therapeutics and Clinical Risk Management. 17: 989–999. doi:10.2147/TCRM.S269336. PMC 8435617. PMID 34526770.
  5. ↑ "Malaria eModule – Exo-Erythrocytic Stages". Archived from the original on 2008-05-27. Retrieved 2023-03-21.
  6. ↑ Chavatte JM, Tan SB, Snounou G, Lin RT (2015). "Molecular characterization of misidentified Plasmodium ovale imported cases in Singapore". Malar J. 14: 454. doi:10.1186/s12936-015-0985-8. PMC 4650842. PMID 26577930.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  7. 1 2 Putaporntip C, Hughes AL, Jongwutiwes S (2013). "Low level of sequence diversity at merozoite surface protein-1 locus of Plasmodium ovale curtisi and P. ovale wallikeri from Thai isolates". PLOS ONE. 8 (3): e58962. Bibcode:2013PLoSO...858962P. doi:10.1371/journal.pone.0058962. PMC 3594193. PMID 23536840.
  8. 1 2 Rutledge GG, Böhme U, Sanders M, Reid AJ, Cotton JA, Maiga-Ascofare O, et al. (February 2017). "Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution". Nature. 542 (7639): 101–104. Bibcode:2017Natur.542..101R. doi:10.1038/nature21038. PMC 5326575. PMID 28117441.
  9. ↑ Nolder D, Oguike MC, Maxwell-Scott H, Niyazi HA, Smith V, Chiodini PL, Sutherland CJ (May 2013). "An observational study of malaria in British travellers: Plasmodium ovale wallikeri and Plasmodium ovale curtisi differ significantly in the duration of latency". BMJ Open. 3 (5): e002711. doi:10.1136/bmjopen-2013-002711. PMC 3657643. PMID 23793668. open access
  10. ↑ Tatem AJ, Jia P, Ordanovich D, Falkner M, Huang Z, Howes R; et al. (2017). "The geography of imported malaria to non-endemic countries: a meta-analysis of nationally reported statistics". Lancet Infect Dis. 17 (1): 98–107. doi:10.1016/S1473-3099(16)30326-7. PMC 5392593. PMID 27777030.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  11. ↑ Faye FB, Konaté L, Rogier C, Trape JF (1998). "Plasmodium ovale in a highly malaria endemic area of Senegal". Transactions of the Royal Society of Tropical Medicine and Hygiene. 92 (5): 522–5. doi:10.1016/S0035-9203(98)90900-2. PMID 9861368.
  12. ↑ Baird JK, Hoffman SL (November 2004). "Primaquine therapy for malaria". Clinical Infectious Diseases. 39 (9): 1336–45. doi:10.1086/424663. PMID 15494911.
  13. ↑ Fuehrer HP, Starzengruber P, Swoboda P, Khan WA, Matt J, Ley B, et al. (July 2010). "Indigenous Plasmodium ovale malaria in Bangladesh". The American Journal of Tropical Medicine and Hygiene. 83 (1): 75–8. doi:10.4269/ajtmh.2010.09-0796. PMC 2912579. PMID 20595481.
  14. ↑ Incardona S, Chy S, Chiv L, Nhem S, Sem R, Hewitt S, et al. (June 2005). "Large sequence heterogeneity of the small subunit ribosomal RNA gene of Plasmodium ovale in Cambodia". The American Journal of Tropical Medicine and Hygiene. 72 (6): 719–24. doi:10.4269/ajtmh.2005.72.719. PMID 15964956. Archived (PDF) from the original on 2019-09-13. Retrieved 2023-03-21.
  15. ↑ Snounou G, Viriyakosol S, Jarra W, Thaithong S, Brown KN (April 1993). "Identification of the four human malaria parasite species in field samples by the polymerase chain reaction and detection of a high prevalence of mixed infections". Molecular and Biochemical Parasitology. 58 (2): 283–92. doi:10.1016/0166-6851(93)90050-8. PMID 8479452.
  16. ↑ Li, Nana; Parker, Daniel M.; Yang, Zhaoqing; Fan, Qi; Zhou, Guofa; Ai, Guoping; Duan, Jianhua; Lee, Ming-chieh; Yan, Guiyun; Matthews, Stephen A.; Cui, Liwang (2013-10-10). "Risk factors associated with slide positivity among febrile patients in a conflict zone of north-eastern Myanmar along the China-Myanmar border". Malaria Journal. 12 (1): 361. doi:10.1186/1475-2875-12-361. ISSN 1475-2875. PMC 3852943. PMID 24112638.
  17. ↑ Cadigan FC, Desowitz RS (1969). "Two cases of Plasmodium ovale malaria from central Thailand". Transactions of the Royal Society of Tropical Medicine and Hygiene. 63 (5): 681–2. doi:10.1016/0035-9203(69)90194-1. PMID 5824291.
  18. ↑ Gleason NN, Fisher GU, Blumhardt R, Roth AE, Gaffney GW (1970). "Plasmodium ovale malaria acquired in Viet-Nam". Bulletin of the World Health Organization. 42 (3): 399–403. PMC 2427544. PMID 4392940.
  19. ↑ "Biology: Malaria (CDC malaria)". Archived from the original on 2008-10-13.
  20. ↑ Markus, MB (2022). "Theoretical origin of genetically homologous Plasmodium vivax malarial recurrences". Southern African Journal of Infectious Diseases. 37 (1): 369. doi:10.4102/sajid.v37i1.369. PMC 8991251. PMID 35399558.
  21. ↑ Fuehrer HP, Noedl H (February 2014). "Recent advances in detection of Plasmodium ovale: implications of separation into the two species Plasmodium ovale wallikeri and Plasmodium ovale curtisi". Journal of Clinical Microbiology. 52 (2): 387–91. doi:10.1128/JCM.02760-13. PMC 3911344. PMID 24478466.
  22. ↑ Radloff PD, Philipps J, Hutchinson D, Kremsner PG (1996). "Atovaquone plus proguanil is an effective treatment for Plasmodium ovale and P. malariae malaria". Transactions of the Royal Society of Tropical Medicine and Hygiene. 90 (6): 682. doi:10.1016/S0035-9203(96)90435-6. PMID 9015517.
  23. ↑ Stephens JWW (8 April 1914). "A new malaria parasite of man". Proc R Soc Lond B. 87 (596): 375–377. Bibcode:1914RSPSB..87..375S. doi:10.1098/rspb.1914.0024.
  • Malaria Archived 2010-12-31 at the Wayback Machine – TDR: For research on diseases of poverty
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