3,3-Diethyl-2-pyrrolidinone

3,3-Diethyl-2-pyrrolidinone (DEABL) is an anticonvulsant drug most closely related to pyrithyldione and gabapentin.[1] It was found to extend lifespan in the nematode worms Caenorhabditis elegans.[2]

3,3-Diethyl-2-pyrrolidinone
Clinical data
ATC code
  • none
Identifiers
  • 3,3-Diethylpyrrolidin-2-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.162.031
Chemical and physical data
FormulaC8H15NO
Molar mass141.214 g·mol−1
3D model (JSmol)
  • CCC1(CC)CCNC1=O
  • InChI=1S/C8H15NO/c1-3-8(4-2)5-6-9-7(8)10/h3-6H2,1-2H3,(H,9,10) checkY
  • Key:WYPUMACPRYGQOM-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

References
  1. Hill MW, Reddy PA, Covey DF, Rothman SM (July 1998). "Contribution of subsaturating GABA concentrations to IPSCs in cultured hippocampal neurons". The Journal of Neuroscience. 18 (14): 5103–11. doi:10.1523/JNEUROSCI.18-14-05103.1998. PMC 6793480. PMID 9651194.
  2. Evason K, Huang C, Yamben I, Covey DF, Kornfeld K (January 2005). "Anticonvulsant medications extend worm life-span". Science. 307 (5707): 258–62. Bibcode:2005Sci...307..258E. doi:10.1126/science.1105299. PMID 15653505. S2CID 22154410.
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