FOXN3

Forkhead box protein N3 is a protein that in humans is encoded by the FOXN3 gene.[3][4]

FOXN3
Identifiers
Aliases	FOXN3, C14orf116, CHES1, PRO1635, forkhead box N3
External IDs	OMIM: 602628 HomoloGene: 3809 GeneCards: FOXN3
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q31.3-q32.11 Start 89,124,871 bp[1] End 89,619,149 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nipple saphenous vein synovial joint cardia vastus lateralis muscle lower lobe of lung superficial temporal artery jejunum urethra body of tongue n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein C-terminus binding protein binding DNA-binding transcription factor activity sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process cell cycle mitotic G2 DNA damage checkpoint signaling negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated transcription, DNA-templated craniofacial suture morphogenesis cell differentiation positive regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1112 n/a Ensembl ENSG00000053254 n/a UniProt O00409 n/a RefSeq (mRNA) NM_005197 NM_001085471 n/a RefSeq (protein) NP_001078940 NP_005188 n/a Location (UCSC) Chr 14: 89.12 – 89.62 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms.[4]