Neurogenin-2
Neurogenin-2 is a protein that in humans is encoded by the NEUROG2 gene.[5]
| NEUROG2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | NEUROG2, Atoh4, Math4A, NGN2, bHLHa8, ngn-2, neurogenin 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 606624 MGI: 109619 HomoloGene: 7633 GeneCards: NEUROG2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Neurogenin-2 is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factor genes that play an important role in neurogenesis.[6]
It has been found to reprogram astrocytes to glutamergic neurons when expressed.[7]
References
- GRCh38: Ensembl release 89: ENSG00000178403 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000027967 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: neurogenin 2".
- Heng JI, Nguyen L, Castro DS, Zimmer C, Wildner H, Armant O, Skowronska-Krawczyk D, Bedogni F, Matter JM, Hevner R, Guillemot F (September 2008). "Neurogenin 2 controls cortical neuron migration through regulation of Rnd2". Nature. 455 (7209): 114–8. Bibcode:2008Natur.455..114H. doi:10.1038/nature07198. PMID 18690213. S2CID 2813030.
- Liu, Fei; Zhang, Yijie; Chen, Fuliang; Yuan, Jiacheng; Li, Sanlan; Han, Sue; Lu, Dengyu; Geng, Junlan; Rao, Zhiping; Sun, Li; Xu, Jianhua; Shi, Yuhan; Wang, Xiaojing; Liu, Yueguang (2021-03-01). "Neurog2 directly converts astrocytes into functional neurons in midbrain and spinal cord". Cell Death & Disease. 12 (3): 225. doi:10.1038/s41419-021-03498-x. ISSN 2041-4889. PMC 7921562. PMID 33649354.
Further reading
- Gradwohl G, Fode C, Guillemot F (1996). "Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors". Dev. Biol. 180 (1): 227–41. doi:10.1006/dbio.1996.0297. PMID 8948587.
- Simmons AD, Horton S, Abney AL, Johnson JE (2001). "Neurogenin2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers". Dev. Biol. 229 (2): 327–39. doi:10.1006/dbio.2000.9984. PMID 11203697.
- Kumar M, Bagchi B, Gupta SK, et al. (2007). "Neurospheres derived from human embryoid bodies treated with retinoic Acid show an increase in nestin and ngn2 expression that correlates with the proportion of tyrosine hydroxylase-positive cells". Stem Cells Dev. 16 (4): 667–81. doi:10.1089/scd.2006.0115. PMID 17784840.
- Deng S, Deng H, Le W, et al. (2009). "Genetic analysis of the NEUROG2 gene in patients with Parkinson's disease". Neurosci. Lett. 468 (3): 195–197. doi:10.1016/j.neulet.2009.10.078. PMID 19879328. S2CID 27698762.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Park CH, Kang JS, Yoon EH, et al. (2008). "Proneural bHLH neurogenin 2 differentially regulates Nurr1-induced dopamine neuron differentiation in rat and mouse neural precursor cells in vitro". FEBS Lett. 582 (5): 537–42. doi:10.1016/j.febslet.2008.01.018. PMID 18242186. S2CID 33390799.
- Fode C, Gradwohl G, Morin X, et al. (1998). "The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons". Neuron. 20 (3): 483–94. doi:10.1016/S0896-6273(00)80989-7. PMID 9539123. S2CID 16790307.
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