GTF2E1

GTF2E1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1VD4, 2JTX, 2RNQ, 2RNR, 5IY9, 5IYC, 5IYD, 5IY7, 5IYA, 5IY6, 5IYB, 5IY8
Identifiers
Aliases	GTF2E1, FE, TF2E1, TFIIE-A, general transcription factor IIE subunit 1
External IDs	OMIM: 189962 MGI: 1921447 HomoloGene: 38062 GeneCards: GTF2E1
Gene location (Human)
Chr.	Chromosome 3 (human)[1]
End	120,783,069 bp[1]
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)[2]
End	37,360,151 bp[2]
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; periodontal fiber; ; sperm; ; monocyte; ; stromal cell of endometrium; ; islet of Langerhans; ; tibia; ; embryo; ; cancellous bone;
	Top expressed in
	hand; ; superior cervical ganglion; ; endocardial cushion; ; primitive streak; ; medial ganglionic eminence; ; abdominal wall; ; atrioventricular valve; ; iris; ; trigeminal ganglion; ; maxillary prominence;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; sequence-specific DNA binding; protein binding; RNA polymerase II complex binding; TFIIH-class transcription factor complex binding; RNA polymerase II general transcription initiation factor activity;
Cellular component	nucleus; nucleoplasm; transcription factor TFIID complex; cytosol; transcription preinitiation complex; transcription factor TFIIE complex;
Biological process	regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription, DNA-templated; transcription initiation from RNA polymerase II promoter; snRNA transcription by RNA polymerase II; viral process; transcription open complex formation at RNA polymerase II promoter;
	Sources:Amigo / QuickGO
Orthologs
	2960
	74197
	ENSG00000153767
	ENSMUSG00000022828
	P29083
	Q9D0D5
	NM_005513
	NM_028812; NM_001355727
	NP_005504
	NP_083088; NP_001342656
	Wikidata
View/Edit Human	View/Edit Mouse

General transcription factor IIE subunit 1 (GTF2E1), also known as transcription initiation factor IIE subunit alpha (TFIIE-alpha), is a protein that in humans is encoded by the GTF2E1 gene.[5]

References

GRCh38: Ensembl release 89: ENSG00000153767 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022828 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: general transcription factor IIE".

Jeronimo C, Forget D, Bouchard A, Li Q, Chua G, Poitras C, Thérien C, Bergeron D, Bourassa S, Greenblatt J, Chabot B, Poirier GG, Hughes TR, Blanchette M, Price DH, Coulombe B (July 2007). "Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme". Molecular Cell. 27 (2): 262–74. doi:10.1016/j.molcel.2007.06.027. PMC 4498903. PMID 17643375.
Langelier MF, Forget D, Rojas A, Porlier Y, Burton ZF, Coulombe B (October 2001). "Structural and functional interactions of transcription factor (TF) IIA with TFIIE and TFIIF in transcription initiation by RNA polymerase II". The Journal of Biological Chemistry. 276 (42): 38652–7. doi:10.1074/jbc.M106422200. PMC 4492724. PMID 11509574.
Vega A, Salas A, Milne RL, Carracedo B, Ribas G, Ruibal A, de León AC, González-Hernández A, Benítez J, Carracedo A (January 2009). "Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study". Gynecologic Oncology. 112 (1): 210–4. doi:10.1016/j.ygyno.2008.09.012. PMID 18950845.
Yamamoto S, Watanabe Y, van der Spek PJ, Watanabe T, Fujimoto H, Hanaoka F, Ohkuma Y (January 2001). "Studies of nematode TFIIE function reveal a link between Ser-5 phosphorylation of RNA polymerase II and the transition from transcription initiation to elongation". Molecular and Cellular Biology. 21 (1): 1–15. doi:10.1128/MCB.21.1.1-15.2001. PMC 86563. PMID 11113176.
Watanabe T, Hayashi K, Tanaka A, Furumoto T, Hanaoka F, Ohkuma Y (April 2003). "The carboxy terminus of the small subunit of TFIIE regulates the transition from transcription initiation to elongation by RNA polymerase II". Molecular and Cellular Biology. 23 (8): 2914–26. doi:10.1128/mcb.23.8.2914-2926.2003. PMC 152561. PMID 12665589.
Jawhari A, Uhring M, De Carlo S, Crucifix C, Tocchini-Valentini G, Moras D, Schultz P, Poterszman A (May 2006). "Structure and oligomeric state of human transcription factor TFIIE". EMBO Reports. 7 (5): 500–5. doi:10.1038/sj.embor.7400663. PMC 1479554. PMID 16547462.
Orphanides G, Lagrange T, Reinberg D (November 1996). "The general transcription factors of RNA polymerase II". Genes & Development. 10 (21): 2657–83. doi:10.1101/gad.10.21.2657. PMID 8946909.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Archambault J, Pan G, Dahmus GK, Cartier M, Marshall N, Zhang S, Dahmus ME, Greenblatt J (October 1998). "FCP1, the RAP74-interacting subunit of a human protein phosphatase that dephosphorylates the carboxyl-terminal domain of RNA polymerase IIO". The Journal of Biological Chemistry. 273 (42): 27593–601. doi:10.1074/jbc.273.42.27593. PMID 9765293.
Kim TK, Ebright RH, Reinberg D (May 2000). "Mechanism of ATP-dependent promoter melting by transcription factor IIH". Science. 288 (5470): 1418–22. Bibcode:2000Sci...288.1418K. doi:10.1126/science.288.5470.1418. PMID 10827951.
Ikeda K, Halle JP, Stelzer G, Meisterernst M, Kawakami K (January 1998). "Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6". Molecular and Cellular Biology. 18 (1): 10–8. doi:10.1128/mcb.18.1.10. PMC 121442. PMID 9418848.
Yu X, Li P, Roeder RG, Wang Z (July 2001). "Inhibition of androgen receptor-mediated transcription by amino-terminal enhancer of split". Molecular and Cellular Biology. 21 (14): 4614–25. doi:10.1128/MCB.21.14.4614-4625.2001. PMC 87125. PMID 11416139.
Di Lello P, Miller Jenkins LM, Mas C, Langlois C, Malitskaya E, Fradet-Turcotte A, Archambault J, Legault P, Omichinski JG (January 2008). "p53 and TFIIEalpha share a common binding site on the Tfb1/p62 subunit of TFIIH". Proceedings of the National Academy of Sciences of the United States of America. 105 (1): 106–11. Bibcode:2008PNAS..105..106D. doi:10.1073/pnas.0707892105. PMC 2224167. PMID 18160537.
Liu L, Ishihara K, Ichimura T, Fujita N, Hino S, Tomita S, Watanabe S, Saitoh N, Ito T, Nakao M (February 2009). "MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity". The Journal of Biological Chemistry. 284 (8): 5165–74. doi:10.1074/jbc.M807098200. PMID 19106100.
Okamoto T, Yamamoto S, Watanabe Y, Ohta T, Hanaoka F, Roeder RG, Ohkuma Y (July 1998). "Analysis of the role of TFIIE in transcriptional regulation through structure-function studies of the TFIIEbeta subunit". The Journal of Biological Chemistry. 273 (31): 19866–76. doi:10.1074/jbc.273.31.19866. PMID 9677423.
Okuda M, Tanaka A, Arai Y, Satoh M, Okamura H, Nagadoi A, Hanaoka F, Ohkuma Y, Nishimura Y (December 2004). "A novel zinc finger structure in the large subunit of human general transcription factor TFIIE". The Journal of Biological Chemistry. 279 (49): 51395–403. doi:10.1074/jbc.M404722200. PMID 15385556.
Okuda M, Tanaka A, Satoh M, Mizuta S, Takazawa M, Ohkuma Y, Nishimura Y (April 2008). "Structural insight into the TFIIE-TFIIH interaction: TFIIE and p53 share the binding region on TFIIH". The EMBO Journal. 27 (7): 1161–71. doi:10.1038/emboj.2008.47. PMC 2275666. PMID 18354501.
Fraser RA, Heard DJ, Adam S, Lavigne AC, Le Douarin B, Tora L, Losson R, Rochette-Egly C, Chambon P (June 1998). "The putative cofactor TIF1alpha is a protein kinase that is hyperphosphorylated upon interaction with liganded nuclear receptors". The Journal of Biological Chemistry. 273 (26): 16199–204. doi:10.1074/jbc.273.26.16199. PMID 9632676.
Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y (March 2010). "An atlas of combinatorial transcriptional regulation in mouse and man". Cell. 140 (5): 744–52. doi:10.1016/j.cell.2010.01.044. PMC 2836267. PMID 20211142.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000153767 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022828 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: general transcription factor IIE".

GTF2E1

See also

References

Further reading