Homarylamine
Homarylamine (INN;[1] also known as 3,4-methylenedioxy-N-methylphenethylamine and MDMPEA) is an antitussive (anti-cough) drug[2] which was patented in 1956 by Merck & Co.,[3] but has never been used medically as such.
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Other names | 1,3-benzodioxolyl-N-methyl-5-ethanamine; 3,4-methylenedioxy-N-methyl-2-phenylethylamine; Norlobivine |
Routes of administration | Various |
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Formula | C10H13NO2 |
Molar mass | 179.219 g·mol−1 |
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Chemically it is a substituted phenethylamine. It is the N-methylated analog of methylenedioxyphenethylamine (MDPEA). It is a schedule I drug in the USA as a positional isomer of MDA.
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Methylenedioxyphenethylamine (MDPEA) for comparison
Reactions
Reaction of homoarylamine with formaldehyde gives hydrastinine.
See also
- Hydrastine, an alkaloid derivative of homarylamine
References
- "International Non-Proprietary Names for Pharmaceutical Preparations" (PDF). Chronicle of the World Health Organization. 12 (3). 1958.
- Stefko PL, Denzel J, Hickey I (March 1961). "Experimental Investigation of Nine Antitussive Drugs". Journal of Pharmaceutical Sciences. 50 (3): 216–221. doi:10.1002/jps.2600500309.
- U.S. Patent 2,820,739
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