MAF (gene)

Transcription factor Maf also known as proto-oncogene c-Maf or V-maf musculoaponeurotic fibrosarcoma oncogene homolog is a transcription factor that in humans is encoded by the MAF gene.[5][6]

MAF
Identifiers
AliasesMAF, CCA4, c-AYGRP, CTRCT21, MAF bZIP transcription factor
External IDsOMIM: 177075 MGI: 96909 HomoloGene: 74552 GeneCards: MAF
Orthologs
SpeciesHumanMouse
Entrez

4094

17132

Ensembl

ENSG00000178573

ENSMUSG00000055435

UniProt

O75444

P54843

RefSeq (mRNA)

NM_001031804
NM_005360

NM_001025577

RefSeq (protein)

NP_001026974
NP_005351

NP_001020748

Location (UCSC)Chr 16: 79.59 – 79.6 MbChr 8: 116.41 – 116.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Types

One type, MafA, also known as RIPE3b1,[7] promotes pancreatic development, as well as insulin gene transcription.[8]

Interactions

MAF has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000178573 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000055435 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)".
  6. Nishizawa M, Kataoka K, Goto N, Fujiwara KT, Kawai S (Oct 1989). "v-maf, a viral oncogene that encodes a "leucine zipper" motif". Proceedings of the National Academy of Sciences of the United States of America. 86 (20): 7711–5. Bibcode:1989PNAS...86.7711N. doi:10.1073/pnas.86.20.7711. PMC 298140. PMID 2554284.
  7. Olbrot M, Rud J, Moss LG, Sharma A (May 2002). "Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA". Proceedings of the National Academy of Sciences of the United States of America. 99 (10): 6737–42. Bibcode:2002PNAS...99.6737O. doi:10.1073/pnas.102168499. PMC 124472. PMID 12011435.
  8. Melloul D, Marshak S, Cerasi E (Mar 2002). "Regulation of insulin gene transcription". Diabetologia. 45 (3): 309–26. doi:10.1007/s00125-001-0728-y. PMID 11914736.
  9. Chen Q, Dowhan DH, Liang D, Moore DD, Overbeek PA (Jul 2002). "CREB-binding protein/p300 co-activation of crystallin gene expression". The Journal of Biological Chemistry. 277 (27): 24081–9. doi:10.1074/jbc.M201821200. PMID 11943779.
  10. Hedge SP, Kumar A, Kurschner C, Shapiro LH (May 1998). "c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation". Molecular and Cellular Biology. 18 (5): 2729–37. doi:10.1128/MCB.18.5.2729. PMC 110652. PMID 9566892.
  11. Huang W, Lu N, Eberspaecher H, De Crombrugghe B (Dec 2002). "A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene". The Journal of Biological Chemistry. 277 (52): 50668–75. doi:10.1074/jbc.M206544200. PMID 12381733.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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