mir-148/mir-152 microRNA precursor family

In molecular biology, miR-148 is a microRNA whose expression has been demonstrated in human (MI0000253), mouse (MI0000550), rat (MI0000616) and zebrafish (MI0002015).[1][2][3] miR-148 has also been predicted in chicken (MI0001189).

mir-148/mir-152 microRNA precursor family
Predicted secondary structure and sequence conservation of mir-148
Identifiers
Symbolmir-148
RfamRF00248
miRBaseMI0000253
miRBase familyMIPF0000056
Other data
RNA typeGene; miRNA
Domain(s)Eukaryota
GOGO:0035195 GO:0035068
SOSO:0001244
PDB structuresPDBe

These predicted hairpin precursor sequence are related to those of miR-152, which has been expressed in mouse (MI0000174) and is predicted in human (MI0000462).[1]

The hairpin precursors (represented here) are predicted based on base pairing and cross-species conservation; their extents are not known. In this case, the mature sequence is excised from the 3' arm of the hairpin.

Targets of miR-148

MicroRNAs act by lowering the expression of genes by binding to target sites in the 3' UTR of the mRNAs. However recently it was shown by Duursma and colleagues that miR-148 down regulates Dnmt3b by binding to a region in the protein coding region.[4]

References
  1. Lagos-Quintana, M; Rauhut R; Yalcin A; Meyer J; Lendeckel W; Tuschl T (2002). "Identification of tissue-specific microRNAs from mouse". Curr Biol. 12 (9): 735–739. doi:10.1016/S0960-9822(02)00809-6. hdl:11858/00-001M-0000-0010-94EF-7. PMID 12007417. S2CID 7901788.
  2. Kim, J; Krichevsky A; Grad Y; Hayes GD; Kosik KS; Church GM; Ruvkun G (2004). "Identification of many microRNAs that copurify with polyribosomes in mammalian neurons". Proc Natl Acad Sci USA. 101 (1): 360–365. Bibcode:2004PNAS..101..360K. doi:10.1073/pnas.2333854100. PMC 314190. PMID 14691248.
  3. Chen, PY; Manninga H; Slanchev K; Chien M; Russo JJ; Ju J; Sheridan R; John B; Marks DS; Gaidatzis D; Sander C; Zavolan M; Tuschl T (2005). "The developmental miRNA profiles of zebrafish as determined by small RNA cloning". Genes Dev. 19 (11): 1288–1293. doi:10.1101/gad.1310605. PMC 1142552. PMID 15937218.
  4. Duursma AM, Kedde M, Schrier M, le Sage C, Agami R (May 2008). "miR-148 targets human DNMT3b protein coding region". RNA. 14 (5): 872–7. doi:10.1261/rna.972008. PMC 2327368. PMID 18367714.


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