mir-399 microRNA precursor family

mir-399 is a microRNA that was identified in both Arabidopsis thaliana and Oryza sativa computationally and was later experimentally verified. mir-399 is thought to target mRNAs coding for a phosphate transporter.[1] The mature sequence is excised from the 3' arm of the hairpin. There are multiple copies of MIR399 in each plant genome, for example A. thaliana contains six microRNA precursors that all give rise to an almost identical mature miR-399 sequence.

mir-399 microRNA precursor family
Predicted secondary structure and sequence conservation of mir-399
Identifiers
Symbolmir-399
RfamRF00445
miRBaseMI0001020
miRBase familyMIPF0000015
Other data
RNA typeGene; miRNA
Domain(s)Eukaryota
GOGO:0035195 GO:0035068
SOSO:0001244
PDB structuresPDBe

References
  1. Jones-Rhoades, MW; Bartel DP (2004). "Computational Identification of Plant MicroRNAs and Their Targets, Including a Stress-Induced miRNA". Mol Cell. 14 (6): 787–799. doi:10.1016/j.molcel.2004.05.027. PMID 15200956.

Further reading
  • Franco-Zorrilla JM, Valli A, Todesco M, et al. (August 2007). "Target mimicry provides a new mechanism for regulation of microRNA activity". Nat. Genet. 39 (8): 1033–7. doi:10.1038/ng2079. PMID 17643101. S2CID 15106802.
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