mir-598 microRNA precursor family

In molecular biology mir-598 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

mir-598
Identifiers
Symbolmir-598
RfamRF01059
miRBase familyMIPF0000393
Other data
RNA typemicroRNA
Domain(s)Eukaryota;
PDB structuresPDBe

miR-598 in senescence

miR-598 has been shown to directly target and inhibit the Sir2 homolog, silent information regulator one (SRT1) enzyme, in the senescence of human adipose-tissue-derived mesenchymal stem cells. Increased miR-598 expression during the senescent state is accompanied by a decreased expression of SRT1, meaning an absence of the inhibited p53 acetylation usually observed with increased STR1 levels.[1] miR-598 acts to modulate cellular senescence. More specifically, its overexpression induces senescence in early-passage cells whilst inhibition conversely sees a partial recovery of the ageing phenotype through increased cellular differentiation.

See also

References
  1. Shin KK, Kim YJ, Hong CP, Yang JW, Bae YC, Jung JS (2012). "miR-598 induces replicative senescence in human adipose tissue-derived mesenchymal stem cells via silent information regulator 1". Mol Cell Biochem. 372 (1–2): 285. doi:10.1007/s11010-012-1330-y. PMID 22581440.

Further reading
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