mir-872 microRNA precursor family
In molecular biology mir-872 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
| mir-872 | |
|---|---|
| Identifiers | |
| Symbol | mir-872 |
| Rfam | RF00918 |
| miRBase family | MIPF0000399 |
| Other data | |
| RNA type | microRNA |
| Domain(s) | Eukaryota; |
| PDB structures | PDBe |
Sertoli Cell Expression
miR-872 has been found to be expressed in sertoli cells and to post-transcriptionally target the Sod-1 gene, which encodes the copper/zinc-binding superoxide dismutase 1 (SOD-1) enzyme.[1] Overproduction of SOD-1 increases oxidative damage and through this results in enhanced apoptosis and cell death.
Insulin-regulated HO-1 expression
Insulin infusion in rats has seen increased levels of heme-oxygenase 1 expression, blocked by inhibited activation of PI3K or protein kinase C. miR-872 levels are reduced with inhibition of adipocytes of the 3T3-L1 cell line, along with those of miRNAs-155 and -183. Insulin is therefore able to increase expression of HO-1 through miR-872 downregulation, as well as via pathways dependent upon PI3K and protein kinase C.[2]
See also
References
- Papaioannou MD, Lagarrigue M, Vejnar CE, Rolland AD, Kühne F, Aubry F, et al. (2011). "Loss of Dicer in Sertoli cells has a major impact on the testicular proteome of mice". Mol Cell Proteomics. 10 (4): M900587–MCP200. doi:10.1074/mcp.M900587-MCP200. PMC 3069350. PMID 20467044.
- Chang CL, Au LC, Huang SW, Fai Kwok C, Ho LT, Juan CC (2011). "Insulin up-regulates heme oxygenase-1 expression in 3T3-L1 adipocytes via PI3-kinase- and PKC-dependent pathways and heme oxygenase-1-associated microRNA downregulation". Endocrinology. 152 (2): 384–93. doi:10.1210/en.2010-0493. PMID 21147878.