mir-3180 microRNA precursor family

In molecular biology mir-3180 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.[1] The mir-10 microRNA precursor is a short non-coding RNA gene that is part of an RNA gene family which contains mir-3180-1, mir-3180-2, mir-3180-3, mir-3180-4 and mir-3180-5. They have now been predicted or experimentally confirmed in a wide range of cancers in humans.[2][3] (MIPF0000894, mir-3180) mir-3180 has currently only been identified in human Homo sapiens.

mir-3180
Conserved secondary structure of the mir-3180 miRNA.
Identifiers
Symbolmir-3180
RfamRF02010
miRBase familyMIPF0000894
HGNC38382
Other data
RNA typemicroRNA
Domain(s)Eukaryota; Metazoa
PDB structuresPDBe

Species distribution

The presence of mir-3180 has been detected in a range of catarrhine monkeys. It has been identified in primates including human (Homo sapiens), Sumatran orangutan (Pongo abelii), western lowland gorilla (Gorilla gorilla gorilla), Northern white-cheeked gibbon (Nomascus leucogenys), Chlorocebus sabaeus (Chlorocebus sabaeus), Olive baboon (Papio anubis) and Rhesus monkey (Macaca mulatta).[4][5] In some of these species the presence of mir-3180 has been shown experimentally, in others the genes encoding mir-3180 might have been predicted computationally.

Genomic location

The mir-3180 genes are found within the Chromosome 16. In humans there are five mir-3180 clusters, these contain five genes encoding miRNAs (mir-3180-1, mir-3180-2, mir-3180-3, mir-3180-4 and mir-3180-5). The mir-3180 genes have the following locations:

hsa-mir-3180-1 chr16 Start: 14911220 End: 14911313 Strand: +

hsa-mir-3180-2 chr16 Start: 16309879 End: 16309966 Strand: +

hsa-mir-3180-3 chr16 Start: 18402178 End: 18402271 Strand: -

hsa-mir-3180-4 chr16 Start: 15154850 End: 15155002 Strand: -

hsa-mir-3180-5 chr16 Start: 2135977 End: 2136129 Strand: -

Association with cancer

Recently there has been much interest in abnormal levels of expression of microRNAs in cancers. Upregulation of mir-3180 has been found in cancers. Increased levels of mir-3180 have been found in colon cancer.[6]

See also

Further reading
  1. Qureshi A, Thakur N, Monga I, Thakur A, Kumar M (1 January 2014). "VIRmiRNA: a comprehensive resource for experimentally validated viral miRNAs and their targets". Database. 2014: bau103. doi:10.1093/database/bau103. PMC 4224276. PMID 25380780.
  2. Jin L, Zhang Z (December 2020). "Serum miR-3180-3p and miR-124-3p may Function as Noninvasive Biomarkers of Cisplatin Resistance in Gastric Cancer". Clinical Laboratory. 66 (12). doi:10.7754/Clin.Lab.2020.200302. PMID 33337849.
  3. Sayagués JM, Corchete LA, Gutiérrez ML, Sarasquete ME, Del Mar Abad M, Bengoechea O, et al. (November 2016). "Genomic characterization of liver metastases from colorectal cancer patients". Oncotarget. 7 (45): 72908–72922. doi:10.18632/oncotarget.12140. PMC 5341953. PMID 27662660.
  4. Creighton CJ, Benham AL, Zhu H, Khan MF, Reid JG, Nagaraja AK, et al. (March 2010). "Discovery of novel microRNAs in female reproductive tract using next generation sequencing". PLOS ONE. 5 (3): e9637. Bibcode:2010PLoSO...5.9637C. doi:10.1371/journal.pone.0009637. PMC 2835764. PMID 20224791.
  5. Stark MS, Tyagi S, Nancarrow DJ, Boyle GM, Cook AL, Whiteman DC, et al. (March 2010). "Characterization of the Melanoma miRNAome by Deep Sequencing". PLOS ONE. 5 (3): e9685. Bibcode:2010PLoSO...5.9685S. doi:10.1371/journal.pone.0009685. PMC 2837346. PMID 20300190.
  6. Hamfjord J, Stangeland AM, Hughes T, Skrede ML, Tveit KM, Ikdahl T, Kure EH (2012). Cho WC (ed.). "Differential expression of miRNAs in colorectal cancer: comparison of paired tumor tissue and adjacent normal mucosa using high-throughput sequencing". PLOS ONE. 7 (4): e34150. Bibcode:2012PLoSO...734150H. doi:10.1371/journal.pone.0034150. PMC 3328481. PMID 22529906.
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