Neurogenin-2

Neurogenin-2 is a protein that in humans is encoded by the NEUROG2 gene.[5]

NEUROG2
Identifiers
AliasesNEUROG2, Atoh4, Math4A, NGN2, bHLHa8, ngn-2, neurogenin 2
External IDsOMIM: 606624 MGI: 109619 HomoloGene: 7633 GeneCards: NEUROG2
Orthologs
SpeciesHumanMouse
Entrez

63973

11924

Ensembl

ENSG00000178403

ENSMUSG00000027967

UniProt

Q9H2A3

P70447

RefSeq (mRNA)

NM_024019

NM_009718

RefSeq (protein)

NP_076924

NP_033848

Location (UCSC)Chr 4: 112.51 – 112.52 MbChr 3: 127.43 – 127.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neurogenin-2 is a member of the neurogenin subfamily of basic helix-loop-helix (bHLH) transcription factor genes that play an important role in neurogenesis.[6]

It has been found to reprogram astrocytes to glutamergic neurons when expressed.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000178403 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000027967 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: neurogenin 2".
  6. Heng JI, Nguyen L, Castro DS, Zimmer C, Wildner H, Armant O, Skowronska-Krawczyk D, Bedogni F, Matter JM, Hevner R, Guillemot F (September 2008). "Neurogenin 2 controls cortical neuron migration through regulation of Rnd2". Nature. 455 (7209): 114–8. Bibcode:2008Natur.455..114H. doi:10.1038/nature07198. PMID 18690213. S2CID 2813030.
  7. Liu, Fei; Zhang, Yijie; Chen, Fuliang; Yuan, Jiacheng; Li, Sanlan; Han, Sue; Lu, Dengyu; Geng, Junlan; Rao, Zhiping; Sun, Li; Xu, Jianhua; Shi, Yuhan; Wang, Xiaojing; Liu, Yueguang (2021-03-01). "Neurog2 directly converts astrocytes into functional neurons in midbrain and spinal cord". Cell Death & Disease. 12 (3): 225. doi:10.1038/s41419-021-03498-x. ISSN 2041-4889. PMC 7921562. PMID 33649354.

Further reading


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