Pituitary-specific positive transcription factor 1

POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1), also known as POU1F1, is a transcription factor for growth hormone.[5]

POU1F1
Identifiers
AliasesPOU1F1, CPHD1, GHF-1, PIT1, POU1F1a, Pit-1, POU class 1 homeobox 1
External IDsOMIM: 173110 MGI: 97588 HomoloGene: 259 GeneCards: POU1F1
Orthologs
SpeciesHumanMouse
Entrez

5449

18736

Ensembl

ENSG00000064835

ENSMUSG00000004842

UniProt

P28069

Q00286

RefSeq (mRNA)

NM_001122757
NM_000306

NM_008849
NM_001362468

RefSeq (protein)

NP_000297
NP_001116229

NP_032875
NP_001349397

Location (UCSC)Chr 3: 87.26 – 87.28 MbChr 16: 65.32 – 65.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 (MIM 164175) of mammals, and Unc-86 of C. elegans (Herr et al., 1988). PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone (GH; MIM 139250) and prolactin (PRL; MIM 176760). PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit (TSHB; MIM 188540) by thyrotropin-releasing hormone (TRH; MIM 257120) and cyclic AMP.[supplied by OMIM][5]

Interactions

Pituitary-specific positive transcription factor 1 has been shown to interact with GATA2[6] and PITX1.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000064835 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000004842 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: POU1F1 POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)".
  6. Dasen JS, O'Connell SM, Flynn SE, Treier M, Gleiberman AS, Szeto DP, Hooshmand F, Aggarwal AK, Rosenfeld MG (May 1999). "Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types". Cell. 97 (5): 587–98. doi:10.1016/S0092-8674(00)80770-9. PMID 10367888. S2CID 15737684.
  7. Szeto DP, Ryan AK, O'Connell SM, Rosenfeld MG (July 1996). "P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7706–10. Bibcode:1996PNAS...93.7706S. doi:10.1073/pnas.93.15.7706. PMC 38811. PMID 8755540.

Further reading

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