Protein AATF

Protein AATF, also known as apoptosis-antagonizing transcription factor is a protein that in humans is encoded by the AATF gene.[5][6][7]

AATF
Identifiers
AliasesAATF, BFR2, CHE-1, CHE1, DED, Apoptosis-antagonizing transcription factor, apoptosis antagonizing transcription factor
External IDsOMIM: 608463 MGI: 1929608 HomoloGene: 40811 GeneCards: AATF
Orthologs
SpeciesHumanMouse
Entrez

26574

56321

Ensembl

ENSG00000275700
ENSG00000276072

ENSMUSG00000018697

UniProt

Q9NY61

Q9JKX4

RefSeq (mRNA)

NM_012138

NM_019816

RefSeq (protein)

NP_036270

NP_062790

Location (UCSC)Chr 17: 36.95 – 37.06 MbChr 11: 84.42 – 84.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.[7]

Interactions

Protein AATF has been shown to interact with:

References

  1. ENSG00000276072 GRCh38: Ensembl release 89: ENSG00000275700, ENSG00000276072 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000018697 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lindfors K, Halttunen T, Huotari P, Nupponen N, Vihinen M, Visakorpi T, Mäki M, Kainulainen H (Sep 2000). "Identification of novel transcription factor-like gene from human intestinal cells". Biochemical and Biophysical Research Communications. 276 (2): 660–6. doi:10.1006/bbrc.2000.3480. PMID 11027528.
  6. Fanciulli M, Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C (May 2000). "Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb". FASEB Journal. 14 (7): 904–12. doi:10.1096/fasebj.14.7.904. PMID 10783144. S2CID 43175069.
  7. "Entrez Gene: AATF apoptosis antagonizing transcription factor".
  8. Guo Q, Xie J (Feb 2004). "AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4". The Journal of Biological Chemistry. 279 (6): 4596–603. doi:10.1074/jbc.M309811200. PMID 14627703.
  9. Bruno T, De Angelis R, De Nicola F, Barbato C, Di Padova M, Corbi N, Libri V, Benassi B, Mattei E, Chersi A, Soddu S, Floridi A, Passananti C, Fanciulli M (Nov 2002). "Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb". Cancer Cell. 2 (5): 387–99. doi:10.1016/s1535-6108(02)00182-4. PMID 12450794.
  10. Di Padova M, Bruno T, De Nicola F, Iezzi S, D'Angelo C, Gallo R, Nicosia D, Corbi N, Biroccio A, Floridi A, Passananti C, Fanciulli M (Sep 2003). "Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter". The Journal of Biological Chemistry. 278 (38): 36496–504. doi:10.1074/jbc.M306694200. PMID 12847090.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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