Rev-Erb

The Rev-Erb proteins are members of the nuclear receptor (NR) superfamily of intracellular transcription factors and key regulatory components of the circadian clock. There are two forms of the receptor, Rev-Erb alpha and Rev-Erb beta, which are each encoded by a separate gene (NR1D1 and NR1D2, respectively).[1][2]  

Diagram showing how REV-ERB regulates circadian gene expression through the secondary loop of the circadian transcription/translation feedback loop (TTFL)
nuclear receptor subfamily 1, group D, member 1
Identifiers
SymbolNR1D1
Alt. symbolsear-1, hRev, Rev-ErbAalpha, THRA1
NCBI gene9572
HGNC7962
OMIM602408
RefSeqNM_021724
UniProtP20393
Other data
LocusChr. 17 q11.2
Search for
StructuresSwiss-model
DomainsInterPro
nuclear receptor subfamily 1, group D, member 2
Identifiers
SymbolNR1D2
Alt. symbolsBD73, RVR, EAR-1r, HZF2, Hs.37288
NCBI gene9975
HGNC7963
OMIM602304
RefSeqXM_001130839
UniProtQ14995
Other data
LocusChr. 3 p24.1
Search for
StructuresSwiss-model
DomainsInterPro

These proteins act as key regulators of clock gene expression through transcriptional repression of Bmal1. Through their regulation of clock-controlled genes, the Rev-Erb proteins affect several physiological processes throughout the body, including metabolic, endocrine, and immune pathways.[3][4][5]

In the NRNC classification scheme, Rev-Erb is nuclear receptor subfamily 1 group D (NR1D). The name "Rev-Erb" derived by truncation from "Rev-ERBA" (Rev-Erbα), which in turn was named because it was on the opposite strand of ERBA (THRA) oncogene. The paralogous Rev-Erbβ does not seem to have anything special on its reverse strand. Older sources may use "Rev-ERBA" as the family name.[6]

See also

References
  1. Lazar MA, Jones KE, Chin WW (March 1990). "Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone". DNA and Cell Biology. 9 (2): 77–83. doi:10.1089/dna.1990.9.77. PMID 1971514.
  2. Dumas B, Harding HP, Choi HS, Lehmann KA, Chung M, Lazar MA, Moore DD (August 1994). "A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb". Molecular Endocrinology. 8 (8): 996–1005. doi:10.1210/mend.8.8.7997240. PMID 7997240.
  3. Scheiermann C, Kunisaki Y, Frenette PS (March 2013). "Circadian control of the immune system". Nature Reviews. Immunology. 13 (3): 190–8. doi:10.1038/nri3386. PMC 4090048. PMID 23391992.
  4. Duez H, Staels B (December 2009). "Rev-erb-alpha: an integrator of circadian rhythms and metabolism". Journal of Applied Physiology. 107 (6): 1972–80. doi:10.1152/japplphysiol.00570.2009. PMC 2966474. PMID 19696364.
  5. Wang S, Li F, Lin Y, Wu B (2020). "Targeting REV-ERBα for therapeutic purposes: promises and challenges". Theranostics. 10 (9): 4168–4182. doi:10.7150/thno.43834. PMC 7086371. PMID 32226546.
  6. PMID 25066191
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