ZNF423

Zinc finger protein 423 is a protein that in humans is encoded by the ZNF423 gene.[5][6][7]

ZNF423
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesZNF423, Ebfaz, JBTS19, NPHP14, OAZ, Roaz, ZFP423, Zfp104, hOAZ, zinc finger protein 423
External IDsOMIM: 604557 MGI: 1891217 HomoloGene: 9010 GeneCards: ZNF423
Orthologs
SpeciesHumanMouse
Entrez

23090

94187

Ensembl

ENSG00000102935

ENSMUSG00000045333

UniProt

Q2M1K9

Q80TS5

RefSeq (mRNA)

NM_001271620
NM_015069
NM_001330533
NM_001379286

NM_033327
NM_001310520

RefSeq (protein)

NP_001258549
NP_001317462
NP_055884
NP_001366215

NP_001297449
NP_201584

Location (UCSC)Chr 16: 49.49 – 49.86 MbChr 8: 88.39 – 88.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development.[7] Mice lacking the homologous gene Zfp423 have defects in midline brain development, especially in the cerebellum,[8][9][10] as well as defects in olfactory development,[11] and adipogenesis.[12][13] Patients with mutations in ZNF423 have been reported in Joubert Syndrome and nephronophthisis.[14]

Interactions

ZNF423 has been shown to interact with EBF1,[15] PARP1,[16] Notch intracellular domain,[17] retinoic acid receptor,[18] and CEP290.[14]

References
  1. GRCh38: Ensembl release 89: ENSG00000102935 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000045333 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  6. Hata A, Seoane J, Lagna G, Montalvo E, Hemmati-Brivanlou A, Massagué J (January 2000). "OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways". Cell. 100 (2): 229–40. doi:10.1016/S0092-8674(00)81561-5. PMID 10660046. S2CID 6145577.
  7. "Entrez Gene: ZNF423 zinc finger protein 423".
  8. Warming S, Rachel RA, Jenkins NA, Copeland NG (September 2006). "Zfp423 is required for normal cerebellar development". Molecular and Cellular Biology. 26 (18): 6913–22. doi:10.1128/MCB.02255-05. PMC 1592861. PMID 16943432.
  9. Alcaraz WA, Gold DA, Raponi E, Gent PM, Concepcion D, Hamilton BA (December 2006). "Zfp423 controls proliferation and differentiation of neural precursors in cerebellar vermis formation". Proceedings of the National Academy of Sciences of the United States of America. 103 (51): 19424–9. Bibcode:2006PNAS..10319424A. doi:10.1073/pnas.0609184103. PMC 1748242. PMID 17151198.
  10. Cheng LE, Zhang J, Reed RR (July 2007). "The transcription factor Zfp423/OAZ is required for cerebellar development and CNS midline patterning". Developmental Biology. 307 (1): 43–52. doi:10.1016/j.ydbio.2007.04.005. PMC 2866529. PMID 17524391.
  11. Cheng LE, Reed RR (May 2007). "Zfp423/OAZ participates in a developmental switch during olfactory neurogenesis". Neuron. 54 (4): 547–57. doi:10.1016/j.neuron.2007.04.029. PMC 2866517. PMID 17521568.
  12. Gupta RK, Arany Z, Seale P, Mepani RJ, Ye L, Conroe HM, Roby YA, Kulaga H, Reed RR, Spiegelman BM (March 2010). "Transcriptional control of preadipocyte determination by Zfp423". Nature. 464 (7288): 619–23. Bibcode:2010Natur.464..619G. doi:10.1038/nature08816. PMC 2845731. PMID 20200519.
  13. Shao M, Hepler C, Vishvanath L, MacPherson KA, Busbuso NC, Gupta RK (January 2017). "Fetal development of subcutaneous white adipose tissue is dependent on Zfp423". Molecular Metabolism. 6 (1): 111–124. doi:10.1016/j.molmet.2016.11.009. PMC 5220400. PMID 28123942.
  14. Chaki M, Airik R, Ghosh AK, Giles RH, Chen R, Slaats GG, et al. (August 2012). "Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling". Cell. 150 (3): 533–48. doi:10.1016/j.cell.2012.06.028. PMC 3433835. PMID 22863007.
  15. Tsai RY, Reed RR (June 1997). "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development". The Journal of Neuroscience. 17 (11): 4159–69. doi:10.1523/jneurosci.17-11-04159.1997. PMC 6573535. PMID 9151733.
  16. Ku MC, Stewart S, Hata A (November 2003). "Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes". Biochemical and Biophysical Research Communications. 311 (3): 702–7. doi:10.1016/j.bbrc.2003.10.053. PMID 14623329.
  17. Masserdotti G, Badaloni A, Green YS, Croci L, Barili V, Bergamini G, Vetter ML, Consalez GG (October 2010). "ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression". The Journal of Biological Chemistry. 285 (40): 30814–24. doi:10.1074/jbc.M110.142869. PMC 2945575. PMID 20547764.
  18. Huang S, Laoukili J, Epping MT, Koster J, Hölzel M, Westerman BA, Nijkamp W, Hata A, Asgharzadeh S, Seeger RC, Versteeg R, Beijersbergen RL, Bernards R (April 2009). "ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome". Cancer Cell. 15 (4): 328–40. doi:10.1016/j.ccr.2009.02.023. PMC 2693316. PMID 19345331.

Further reading

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