TAF2

Transcription initiation factor TFIID subunit 2 is a protein that in humans is encoded by the TAF2 gene.[5][6][7]

TAF2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTAF2, CIF150, MRT40, TAF2B, TAFII150, TATA-box binding protein associated factor 2
External IDsOMIM: 604912 MGI: 2443028 HomoloGene: 31137 GeneCards: TAF2
Orthologs
SpeciesHumanMouse
Entrez

6873

319944

Ensembl

ENSG00000064313

ENSMUSG00000037343

UniProt

Q6P1X5

Q8C176

RefSeq (mRNA)

NM_003184

NM_001081288
NM_177040

RefSeq (protein)

NP_003175

NP_001074757

Location (UCSC)Chr 8: 119.73 – 119.83 MbChr 15: 54.88 – 54.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000064313 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037343 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Martinez E, Ge H, Tao Y, Yuan CX, Palhan V, Roeder RG (Nov 1998). "Novel cofactors and TFIIA mediate functional core promoter selectivity by the human TAFII150-containing TFIID complex". Mol Cell Biol. 18 (11): 6571–83. doi:10.1128/mcb.18.11.6571. PMC 109242. PMID 9774672.
  6. Kaufmann J, Ahrens K, Koop R, Smale ST, Muller R (Jan 1998). "CIF150, a human cofactor for transcription factor IID-dependent initiator function". Mol Cell Biol. 18 (1): 233–9. doi:10.1128/mcb.18.1.233. PMC 121482. PMID 9418870.
  7. "Entrez Gene: TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa".

Further reading

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