Xywav

Xywav, is a medication used to treat cataplexy or excessive daytime sleepiness (EDS).[1][2] It contains a mixture of oxybate salts, namely Calcium oxybate, Magnesium Oxybate, Potassium Oxybate, and Sodium Oxybate.[1] It is taken by mouth.[1]

Xywav
Combination of
Calcium oxybateCNS depressant
Magnesium oxybateCNS depressant
Potassium oxybateCNS depressant
Sodium oxybateCNS depressant
Clinical data
Trade namesXywav
License data
Routes of
administration
By mouth
ATC code
  • None
Legal status
Legal status
Identifiers
KEGG

Manufactured by the Jazz Pharmaceuticals company, it was approved for medical use in the United States in July 2020.[1][3][4]

Medical uses

Xywav is indicated for the treatment of cataplexy in people aged seven years of age and older with narcolepsy.[1][5]

In August 2021, the U.S. Food and Drug Administration (FDA) approved Xywav for the treatment of idiopathic hypersomnia.[5][6]

Side Effects

Breathing Problems

Slowed breathing, Trouble breathing, Sleep apnea[7]

Mental Health Problems

Confusion, Hallucination, Unusual or disturbing thoughts (abnormal thinking), Anxiety, Depression, Suicidal Thoughts or actions, Increased tiredness, feelings of guilt or worthlessness, Difficulty concentrating[7]

Other

Sleepwalking[7]

Society and culture

Xywav was granted orphan drug designation in November 1994 by the U.S. Food and Drug Administration (FDA).[8][5] The FDA granted the approval of Xywav to Jazz Pharmaceuticals plc in August 2021.[5]

Other names

In the testing phase of the drug, it was known as JZP-258 [9]

References

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