Y box binding protein 1

Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene.[5]

YBX1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesYBX1, BP-8, CSDA2, CSDB, DBPB, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1, CBF-A, EFI-A, Y-box binding protein 1
External IDsOMIM: 154030 MGI: 99146 HomoloGene: 88707 GeneCards: YBX1
Orthologs
SpeciesHumanMouse
Entrez

4904

22608

Ensembl

ENSG00000065978

ENSMUSG00000028639

UniProt

P67809

P62960

RefSeq (mRNA)

NM_004559

NM_011732

RefSeq (protein)

NP_004550

NP_035862

Location (UCSC)Chr 1: 42.68 – 42.7 MbChr 4: 119.14 – 119.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Clinical significance

YBX1 is a potential drug target in cancer therapy.[6] YB-1 helps the replication of adenovirus type 5, a commonly used vector in gene therapy.[6] Thus, YB-1 can cause an "oncolytic" effect in YB-1 positive cancer cells treated with adenoviruses.

Interactions

Y box binding protein 1 has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000065978 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028639 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: YBX1 Y box binding protein 1".
  6. Lage H, Surowiak P, Holm PS (November 2008). "[YB-1 as a potential target in cancer therapy]". Pathologe (in German). 29 (Suppl 2): 187–90. doi:10.1007/s00292-008-1030-2. PMID 18773210.
  7. Kojic S, Medeot E, Guccione E, Krmac H, Zara I, Martinelli V, Valle G, Faulkner G (2004). "The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle". J. Mol. Biol. 339 (2): 313–25. doi:10.1016/j.jmb.2004.03.071. PMID 15136035.
  8. Chernukhin IV, Shamsuddin S, Robinson AF, Carne AF, Paul A, El-Kady AI, Lobanenkov VV, Klenova EM (2000). "Physical and functional interaction between two pluripotent proteins, the Y-box DNA/RNA-binding factor, YB-1, and the multivalent zinc finger factor, CTCF". J. Biol. Chem. 275 (38): 29915–21. doi:10.1074/jbc.M001538200. PMID 10906122.
  9. Okamoto T, Izumi H, Imamura T, Takano H, Ise T, Uchiumi T, Kuwano M, Kohno K (2000). "Direct interaction of p53 with the Y-box binding protein, YB-1: a mechanism for regulation of human gene expression". Oncogene. 19 (54): 6194–202. doi:10.1038/sj.onc.1204029. PMID 11175333.
  10. Ise T, Nagatani G, Imamura T, Kato K, Takano H, Nomoto M, Izumi H, Ohmori H, Okamoto T, Ohga T, Uchiumi T, Kuwano M, Kohno K (1999). "Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen". Cancer Res. 59 (2): 342–6. PMID 9927044.
  11. Chibi M, Meyer M, Skepu A, G Rees DJ, Moolman-Smook JC, Pugh DJ (2008). "RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1". J. Mol. Biol. 384 (4): 908–16. doi:10.1016/j.jmb.2008.09.060. PMID 18851979.
  12. Raffetseder U, Frye B, Rauen T, Jürchott K, Royer HD, Jansen PL, Mertens PR (2003). "Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection". J. Biol. Chem. 278 (20): 18241–8. doi:10.1074/jbc.M212518200. PMID 12604611.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.