Heck's disease

Heck's disease, also known as Focal Epithelial Hyperplasia, is an asymptomatic, benign neoplastic condition characterized by multiple white to pinkish papules that occur diffusely in the oral cavity.[1][2]: 411  Can present with slightly pale, smooth or roughened surface morphology. It is caused by the human papilloma virus types 13 and 32.[3] It exhibits surface cells with vacuolated cytoplasm around irregular, pyknotic nuclei and occasional cells with mitosis-like changes within otherwise mature and well-differentiated epithelium. A distinguishing histologic feature is elongated rete ridges with mitosoid bodies. It shows 'cobblestone' appearance clinically. It was first identified in the Aboriginal population of North America.[4]

"Epithelial hyperplasia" redirects here. For epidermis in general, see Epidermal hyperplasia.
Heck's disease
Other namesMultifocal epithelial hyperplasia
SpecialtyOral and maxillofacial surgery 

Over time, they will spontaneously regress without treatment.[5] Possible treatment may be excisional biopsy for lesions of functional or aesthetic concern.

References
  1. Tenore, G.; Palaia, G.; Del Vecchio, A.; Galanakis, A.; Romeo, U. (2013-10-24). "Focal epithelial hyperplasia (Heck's disease)". Annali di Stomatologia. 4 (Suppl 2): 43. ISSN 1824-0852. PMC 3860189. PMID 24353818.
  2. James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
  3. James, William D.; Berger, Timothy; Elston, Dirk (2015). Andrews' Diseases of the Skin E-Book: Clinical Dermatology. Elsevier Health Sciences. p. 408. ISBN 9780323319690.
  4. Archard, Howell O; Heck, John W; Stanley, Harold R (1965). "Focal epithelial hyperplasia: An unusual oral mucosal lesion found in Indian children". Oral Surgery, Oral Medicine, Oral Pathology. 20 (2): 201–12. doi:10.1016/0030-4220(65)90192-1. PMID 14322615.
  5. Eversole, Lewis R. (2011). Clinical Outline of Oral Pathology: Diagnosis and Treatment. PMPH-USA. p. 285. ISBN 9781607950158. Retrieved 18 January 2018.


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