Fostemsavir

Fostemsavir, sold under the brand name Rukobia, is an antiretroviral medication for adults living with HIV/AIDS who have tried multiple HIV medications and whose HIV infection cannot be successfully treated with other therapies because of resistance, intolerance or safety considerations.[4][6]

Fostemsavir
Clinical data
Trade namesRukobia
Other namesBMS-663068, GSK3684934
AHFS/Drugs.comMonograph
MedlinePlusa620046
License data
Pregnancy
category
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
IUPAC name
  • {3-[(4-Benzoyl-1-piperazinyl)(oxo)acetyl]-4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-1-yl}methyl dihydrogen phosphate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC25H26N7O8P
Molar mass583.498 g·mol−1
3D model (JSmol)
SMILES
  • O=C(c1ccccc1)N5CCN(C(=O)C(=O)c4c2c(c(ncc2OC)n3nc(nc3)C)n(c4)COP(=O)(O)O)CC5
InChI
  • InChI=1S/C25H26N7O8P/c1-16-27-14-32(28-16)23-21-20(19(39-2)12-26-23)18(13-31(21)15-40-41(36,37)38)22(33)25(35)30-10-8-29(9-11-30)24(34)17-6-4-3-5-7-17/h3-7,12-14H,8-11,15H2,1-2H3,(H2,36,37,38)
  • Key:SWMDAPWAQQTBOG-UHFFFAOYSA-N

The most common adverse reaction is nausea.[4][6][7] Severe adverse reactions included elevations in liver enzymes among participants also infected with hepatitis B or C virus, and changes in the immune system (immune reconstitution syndrome).[6]

Fostemsavir is an HIV entry inhibitor and a prodrug of temsavir (BMS-626529).[8] Fostemsavir is a human immunodeficiency virus type 1 (HIV-1) gp120-directed attachment inhibitor.[9]

It was approved for medical use in the United States in July 2020,[6][7][9] and in the European Union in February 2021.[5] The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication.[10]

Medical uses

Fostemsavir in combination with other antiretroviral(s), is indicated for the treatment of HIV-1 infection in heavily treatment-experienced adults with multidrug-resistant HIV-1 infection failing their current antiretroviral regimen due to resistance, intolerance, or safety considerations.[9]

Adverse effects

Fostemsavir may cause a serious condition called immune reconstitution syndrome, similar to other approved drugs for treatment of HIV-1 infection.[7] This condition can happen at the beginning of HIV-1 treatment when the immune system may get stronger and begin to fight infections that have been hidden in the body for a long time.[7] Other serious side effects include heart rhythm problems due to prolongation of heart electrical activity (QT prolongation) and an increase of liver enzymes in patients with hepatitis B or C virus co-infection.[7]

History

It was under development by ViiV Healthcare / GlaxoSmithKline for use in the treatment of HIV infection. When the active form of fostemsavir binds to the gp120 protein of the virus, it prevents initial viral attachment to the host CD4+ T cell and entry into the host immune cell; its method of action is a first for HIV drugs.[11] Because it targets a different step of the viral lifecycle, it offers promise for individuals with virus that has become highly resistant to other HIV drugs.[12] Since the function of gp120 that this drug inhibits is highly conserved, the drug is unlikely to promote resistance to itself.[13] Investigators found that enfuvirtide-resistant and ibalizumab-resistant HIV envelopes remained susceptible to fostemsavir. Conversely, fostemsavir-resistant HIV remained susceptible to all the entry inhibitors. Furthermore, HIV isolates that do not require the CD4 receptor for cell entry were also susceptible to fostemsavir, and the virus did not escape the attachment inhibitor by becoming CD4-independent. Prior in vitro studies showed that fostemsavir inhibits both CCR5-tropic and CXCR4-tropic HIV.[11]

Temsavir (BMS-626529)

Fostemsavir was approved for medical use in the United States in July 2020.[6][7][9]

The safety and efficacy of fostemsavir, taken twice daily by mouth, were evaluated in a clinical trial of 371 heavily treatment-experienced adult participants who continued to have high levels of virus (HIV-RNA) in their blood despite being on antiretroviral drugs.[6] Two hundred seventy-two participants were treated in the main trial arm, and an additional 99 participants received fostemsavir in a different arm of the trial.[6][7] Most participants had been treated for HIV for more than 15 years (71 percent), had been exposed to five or more different HIV treatment regimens before entering the trial (85 percent) and/or had a history of AIDS (86 percent).[6] Participants in the main cohort of the trial received either fostemsavir or a placebo twice daily for eight days, in addition to their failing antiretroviral regimen.[6][7] On the eighth day, participants treated with fostemsavir had a significantly greater decrease in levels of HIV-RNA in their blood compared to those taking the placebo.[6] After the eighth day, all participants received fostemsavir with other antiretroviral drugs.[6][7] After 24 weeks of fostemsavir plus other antiretroviral drugs, 53 percent of participants achieved HIV RNA suppression, where levels of HIV were low enough to be considered undetectable.[6] After 96 weeks, 60 percent of participants continued to have HIV RNA suppression.[6]

The clinical trial (NCT02362503) was conducted at 108 sites in 23 countries in North America, South America, Europe, Australia, Taiwan and South Africa.[7]

The U.S. Food and Drug Administration (FDA) granted the application for fostemsavir fast track, priority review, and breakthrough therapy designations.[6] The FDA granted the approval of Rukobia to ViiV Healthcare.[6]

On 10 December 2020, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Rukobia, intended for the treatment of multi-drug resistant HIV-1 infection.[14] The applicant for this medicinal product is ViiV Healthcare B.V. Fostemsavir was approved for medical use in the European Union in February 2021.[5]

References
  1. "Rukobia". Therapeutic Goods Administration (TGA). 23 July 2021. Retrieved 5 September 2021.
  2. "Notice: Multiple Additions to the Prescription Drug List (PDL) [2022-01-24]". Health Canada. 24 January 2022. Retrieved 28 May 2022.
  3. "Summary Basis of Decision (SBD) for Rukobia". Health Canada. Retrieved 29 May 2022.
  4. "Rukobia- fostemsavir tromethamine tablet, film coated, extended release". DailyMed. 2 July 2020. Retrieved 14 July 2020.
  5. "Rukobia EPAR". European Medicines Agency (EMA). 9 December 2020. Retrieved 12 February 2021.
  6. "FDA Approves New HIV Treatment for Patients With Limited Treatment Options". U.S. Food and Drug Administration (Press release). 2 July 2020. Retrieved 2 July 2020. This article incorporates text from this source, which is in the public domain.
  7. "Drug Trials Snapshots: Rukobia". U.S. Food and Drug Administration (FDA). 2 July 2020. Retrieved 14 July 2020. This article incorporates text from this source, which is in the public domain.
  8. Lai, Yen-Ting; Wang, Tao; O'Dell, Sijy; Louder, Mark K.; Schön, Arne; Cheung, Crystal S. F.; Chuang, Gwo-Yu; Druz, Aliaksandr; Lin, Bob; McKee, Krisha; Peng, Dongjun (3 January 2019). "Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry". Nature Communications. 10 (1): 47. Bibcode:2019NatCo..10...47L. doi:10.1038/s41467-018-07851-1. ISSN 2041-1723. PMC 6318274. PMID 30604750.
  9. "ViiV Healthcare Announces US FDA Approval for Rukobia (fostemsavir), a First-in-Class Treatment for HIV in Adults With Few Treatment Options Available" (Press release). ViiV Healthcare. 2 July 2020. Retrieved 2 July 2020 – via Business Wire.
  10. "New Drug Therapy Approvals 2020". U.S. Food and Drug Administration (FDA). 31 December 2020. Retrieved 17 January 2021. This article incorporates text from this source, which is in the public domain.
  11. "HIV Attachment Inhibitor BMS-663068 Looks Good in Early Studies". Archived from the original on 2 June 2021. Retrieved 28 May 2014.
  12. HIV attachment inhibitor BMS-663068 shows good safety and efficacy in phase 2b study
  13. "Activity of the HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068, against CD4-independent viruses and HIV-1 envelopes resistant to other entry inhibitors". Archived from the original on 1 November 2018. Retrieved 29 May 2014.
  14. "Rukobia: Pending EC decision". European Medicines Agency (EMA). 11 December 2020. Retrieved 11 December 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

Further reading
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