Iotapapillomavirus

Iotapapillomavirus is a genus of viruses, in the family Papillomaviridae.[1] Rodents serve as natural hosts. There are two species in this genus. Diseases associated with this genus include: cutaneous lesions and benign skin tumours, such as papillomas and keratoacanthomas.[2][3]

Iotapapillomavirus
Virus classification
(unranked): Virus
Realm: Monodnaviria
Kingdom: Shotokuvirae
Phylum: Cossaviricota
Class: Papovaviricetes
Order: Zurhausenvirales
Family: Papillomaviridae
Genus: Iotapapillomavirus

Taxonomy

The following two species are assigned to the genus:[3]

Structure

Viruses in Iotapapillomavirus are non-enveloped, with icosahedral geometries, and T=7 symmetry. The diameter is around 60 nm. Genomes are circular, around 8kb in length.[2]

GenusStructureSymmetryCapsidGenomic arrangementGenomic segmentation
IotapapillomavirusIcosahedralT=7Non-envelopedCircularMonopartite

Life cycle

Viral replication is nuclear. Entry into the host cell is achieved by attachment of the viral proteins to host receptors, which mediates endocytosis. Replication follows the dsDNA bidirectional replication model. DNA-templated transcription, with some alternative splicing mechanism is the method of transcription. The virus exits the host cell by nuclear envelope breakdown. Rodents serve as the natural host. Transmission routes are contact.[2]

GenusHost detailsTissue tropismEntry detailsRelease detailsReplication siteAssembly siteTransmission
IotapapillomavirusRodentsEpithelial: mucous; epithelial: skinCell receptor endocytosisLysisNucleusNucleusContact

References
  1. Van Doorslaer, K; Chen, Z; Bernard, HU; Chan, PKS; DeSalle, R; Dillner, J; Forslund, O; Haga, T; McBride, AA; Villa, LL; Burk, RD; ICTV Report Consortium (August 2018). "ICTV Virus Taxonomy Profile: Papillomaviridae". The Journal of General Virology. 99 (8): 989–990. doi:10.1099/jgv.0.001105. PMC 6171710. PMID 29927370.
  2. "Viral Zone". ExPASy. Retrieved 15 June 2015.
  3. "Virus Taxonomy: 2020 Release". International Committee on Taxonomy of Viruses (ICTV). March 2021. Retrieved 10 May 2021.
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