Lifitegrast

Lifitegrast
Names
PronunciationXiidra /ˈzaɪdrə/[1]
Trade namesXiidra
Other namesSAR-1118
IUPAC name
  • N-{[2-(1-Benzofuran-6-ylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl}-3-(methylsulfonyl)-L-phenylalanine
Clinical data
Main usesDry eyes[2]
Side effectsBlurry vision, red eyes, headache, change in taste, itchiness[2]
WHO AWaReUnlinkedWikibase error: ⧼unlinkedwikibase-error-statements-entity-not-set⧽
Pregnancy
category
  • AU: B1
  • US: N (Not classified yet)
    Routes of
    use    		Eye drops
    External links
    AHFS/Drugs.comMonograph
    MedlinePlusa616039
    Legal
    Legal status
    • AU: S4 (Prescription only)
    • US: ℞-only
    Chemical and physical data
    FormulaC29H24Cl2N2O7S
    Molar mass615.48 g·mol−1
    3D model (JSmol)
    SMILES
    • CS(=O)(=O)c1cccc(c1)C[C@@H](C(=O)O)NC(=O)c2c(cc3c(c2Cl)CCN(C3)C(=O)c4ccc5ccoc5c4)Cl
    InChI
    • InChI=1S/C29H24Cl2N2O7S/c1-41(38,39)20-4-2-3-16(11-20)12-23(29(36)37)32-27(34)25-22(30)13-19-15-33(9-7-21(19)26(25)31)28(35)18-6-5-17-8-10-40-24(17)14-18/h2-6,8,10-11,13-14,23H,7,9,12,15H2,1H3,(H,32,34)(H,36,37)/t23-/m0/s1
    • Key:JFOZKMSJYSPYLN-QHCPKHFHSA-N

    Lifitegrast, sold under the brand name Xiidra, is a medication used to treat dry eyes.[2] It is unclear if its benefits are greater than its harms.[3][4] It is used as eye drops.[2]

    Common side effects include blurry vision, red eyes, headache, change in taste, and itchiness.[2] Safety in pregnancy is not clear.[5] It reduces inflammation by inhibiting T cells.[3]

    Lifitegrast was approved for medical use in the United States in 2016.[2] It is not approved in either the United Kingdom or Europe.[3][4] In the United States it costs about 580 USD per month as of 2021.[6]

    Medical uses

    Dosage

    It is used as once drop twice per day of 5% solution.[2] Lifitegrast is supplied as an eye drop.

    Side effects

    Common side effects in clinical trials were eye irritation, discomfort, blurred vision, and dysgeusia (a distortion of the sense of taste).[7]

    Pharmacology

    Mechanism of action

    Lifitegrast inhibits an integrin, lymphocyte function-associated antigen 1 (LFA-1), from binding to intercellular adhesion molecule 1 (ICAM-1). This mechanism down-regulates inflammation mediated by T lymphocytes.[8][9]

    History

    Lifitegrast was initially designed and developed by SARcode Bioscience[10] which was acquired by Shire in 2013,[11] which submitted a new drug application to the US Food and Drug Administration (FDA) in March 2015. The FDA granted Shire a priority review a month later, and requested additional clinical data, which were supplied in January 2016; approval was granted on 11 July 2016.[12][13] Lifitegrast was approved by Health Canada in January 2018, and available in Canadian pharmacies as of March 2018.

    Shire was acquired by Takeda Pharmaceutical Company in late 2018.[14] In May 2019 Novartis reached an agreement to purchase the assets associated with Lifitegrast. Novartis will pay Takeda an upfront payment of $3.4 billion, while the latter drugmaker is eligible for milestone payments of as much as $1.9 billion. Novartis noted that the drug amassed approximately $400 million in revenue in 2018.[15]

    Society and culture

    Cost

    The medication is sold in the U.S. at a cost of $587 (USD) for 60 solution(s) ophthalmic solution 5% [16]

    • Lifitegrast costs (US)
      Lifitegrast costs (US)
    • Lifitegrast prescriptions (US)
      Lifitegrast prescriptions (US)

    References

    1. ↑ "Patient information: Xiidra® (ZYE-druh) (lifitegrast ophthalmic solution) 5% for topical ophthalmic use" (PDF). Novartis. June 2020. Archived (PDF) from the original on 2021-02-13. Retrieved 2021-02-05.
    2. 1 2 3 4 5 6 7 "Lifitegrast Monograph for Professionals". Drugs.com. Archived from the original on 5 March 2021. Retrieved 22 November 2021.
    3. 1 2 3 "Lifitegrast". SPS - Specialist Pharmacy Service. 8 February 2016. Archived from the original on 11 December 2021. Retrieved 23 November 2021.
    4. 1 2 "Xiidra: Withdrawal of the marketing authorisation application". Archived from the original on 14 November 2021. Retrieved 23 November 2021.
    5. ↑ "Lifitegrast ophthalmic (Xiidra) Use During Pregnancy". Drugs.com. Archived from the original on 28 November 2020. Retrieved 23 November 2021.
    6. ↑ "Lifitegrast Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 28 October 2016. Retrieved 23 November 2021.
    7. ↑ Drugs.com: Patient information for xiidra.
    8. ↑ Tauber J, Karpecki P, Latkany R, Luchs J, Martel J, Sall K, et al. (December 2015). "Lifitegrast Ophthalmic Solution 5.0% versus Placebo for Treatment of Dry Eye Disease: Results of the Randomized Phase III OPUS-2 Study". Ophthalmology. 122 (12): 2423–31. doi:10.1016/j.ophtha.2015.08.001. PMID 26365210.
    9. ↑ Murphy CJ, Bentley E, Miller PE, McIntyre K, Leatherberry G, Dubielzig R, et al. (May 2011). "The pharmacologic assessment of a novel lymphocyte function-associated antigen-1 antagonist (SAR 1118) for the treatment of keratoconjunctivitis sicca in dogs". Investigative Ophthalmology & Visual Science. 52 (6): 3174–80. doi:10.1167/iovs.09-5078. PMID 21330663.
    10. ↑ Semba CP, Gadek TR (2016). "Development of lifitegrast: a novel T-cell inhibitor for the treatment of dry eye disease". Clinical Ophthalmology. 10: 1083–94. doi:10.2147/OPTH.S110557. PMC 4910612. PMID 27354762.
    11. ↑ "Shire To Acquire Sarcode Bioscience, Expands Presence In Ophthalmology". 25 March 2013. Archived from the original on 26 November 2017. Retrieved 16 September 2016.
    12. ↑ "FDA Approves Shire's Xiidra". 11 July 2016. Archived from the original on 17 August 2016. Retrieved 13 July 2016.
    13. ↑ Drugs.com: Xiidra (lifitegrast) FDA Approval History Archived 2016-09-14 at the Wayback Machine
    14. ↑ "Takeda Completes Acquisition of Shire, Becoming a Global, Values-based, R&D-Driven Biopharmaceutical Leader". Takeda. January 8, 2019. Archived from the original on June 24, 2021. Retrieved May 13, 2019.
    15. ↑ "Novartis to acquire Xiidra, expanding front-of-eye portfolio and strengthening leadership in eye care". Novartis (Press release). May 9, 2019. Archived from the original on May 13, 2019. Retrieved May 13, 2019.
    16. ↑ "Xiidra Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 17 January 2021. Retrieved 3 April 2021.
    Identifiers:
    This article is issued from Offline. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.