Nucleocytoviricota

Nucleocytoviricota
Virus classification
(unranked): Virus
Realm: Varidnaviria
Kingdom: Bamfordvirae
Phylum: Nucleocytoviricota
Classes

See text

Synonyms

Megavirales[1]

Nucleocytoviricota is a phylum of viruses.[2] Members of the phylum are also known as the nucleocytoplasmic large DNA viruses (NCLDV), which serves as the basis of the name of the phylum with the suffix -viricota for virus phylum. These viruses are referred to as nucleocytoplasmic because they are often able to replicate in both the host's cell nucleus and cytoplasm.[3]

The phylum is notable for containing the giant viruses.[4][1] There are nine families of NCLDVs that all share certain genomic and structural characteristics; however, it is uncertain whether the similarities of the different families of this group have a common viral ancestor.[5] One feature of this group is a large genome and the presence of many genes involved in DNA repair, DNA replication, transcription, and translation. Typically, viruses with smaller genomes do not contain genes for these processes. Most of the viruses in this family also replicate in both the host's nucleus and cytoplasm, thus the name nucleocytoplasmic.

There are 47 NCLDV core genes currently recognised. These include four key proteins involved in DNA replication and repair: the enzymes DNA polymerase family B, the topoisomerase II A, the FLAP endonuclease and the processing factor proliferating cell nuclear antigen. Other proteins include DNA dependent RNA polymerase II and transcription factor II B.

Taxonomy

The following classes are recognized, under which are orders that contain families mentioned in this article:

The unrecognized families are parenthesized and placed in the most likely location.

Hosts

Host organisms typically include protozoa, invertebrates and eukaryotic algae.

Phylogenetic tree of phylum Nucleocytoviricota on base of Subramaniam et al. (2020).[6]

Examples

Ascoviridae

Order Pimascovirales. Members of the family Ascoviridae come in different shapes. Some can be rod-shaped, while others are oval. They measure up to 130 nm wide and 400 nm long. Theses viruses have circular double stranded DNA that have a length of about 100–200 kilobase pairs. They infect lepidopteran insect larvae and can infect through parasitoid wasps. Once they infect they replicate and cause death in insect pest. This allows them to control insect populations.[7] Ascoviridae can have up to 180 genes in its genome. The replication of this virus takes place in the nucleus of the host cell. When it replicates, it causes the nucleus to increase in size and eventually burst. After, the virion starts to form and spread.[8]

Asfarviridae

Order Asfuvirales. A member of the family Asfarviridae is a known as an asfarvirus. This virus is the cause of African swine fever. Some of the symptoms for this flu include fever, high pulse, fast breathing, and it can cause death. These symptoms can be similar to those from hog cholera, the difference is that the African swine flu can not be cured. There is no vaccine developed to fight this virus.[9]

Iridoviridae

Order Pimascovirales. The Iridoviridae have linear double stranded DNA genomes up to 220 kilobases long and can code for about 211 proteins. The capsid of this virion is icosahedral shaped and can be up to 350 nm wide. The replication cycle of this virus begins in the nucleus of the host and end in the cytoplasm. Some viruses of this family are often found infecting fish and amphibians while other are found in insect and crustaceans.[10]

Marseilleviridae

Order Pimascovirales. The Marseilleviridae viruses have double stranded DNA genomes that are about 368 kilobases long. Members of the family can have about 457 open reading frames (ORFs) in its genome. The host organisms are amoebae. Once it infects, viral replication takes place in virus factories in the cytoplasm. It was found that the genome of the family Marseilleviridae codes for about 28 different proteins.[11] The capsid of the marseillevirus is about 250 nm wide with a geometry shape of an icosahedral. The replication of this virus usually occurs near the nucleus once it infects the amoeba. Once the virus infects it can cause a shape change in the host’s nucleus.[12]

Mimiviridae

Order Imitervirales. The Megaviridae contains some of the largest viruses ever discovered. They have linear double stranded DNA genomes with the length of 1,259,197 base pairs, which is larger than some small bacteria. Within in this genome 1,100 proteins are coded. 74.76% of the base pairs are represented by thymine and adenine. The Megaviridae virus can be found infecting acanthamoeba or other protozoan clades.  Once the virus infects the host, the replication cycle takes place in the cytoplasm. Within the genome, DNA repair enzymes can be found. These are used when the DNA is harmed such as when it is exposed to ionizing radiation or UV light.[13]

Traditionally only these viruses have been grouped into a family Mimiviridae. Later it appeared that the viruses of the Organic Lake Phycodna Group (OLPG) are more related to Mimiviruses than to Phycodnaviruses. For this reason it has been proposed adding them to legacy Mimiviridae as new subfamily Mesomimivirinae in order to form the more comprehensive family Megaviridae. For this reason, the term Mimiviridae was used sensu lato synonymous with Megaviridae.[14][15][16][17][18][19] However, since the ICTV has created a new order Imitervirales officially containing the (legacy) Mimiviridae, proposed Mesomimivirinae are proposed to be upgraded as a new family Mesomimiviridae, i. e. as sister family of legacy Mimiviridae (within this order).

Pandoraviridae

Possibly order Algavirales. Pandoraviridae Discovered in 2013 from a coastal water sample in Chile. It is mostly found infecting amoebae. It has a length of 1 micrometer long and .5 micrometer wide. Its genome can be up to 2.5 million base pairs long.[20] The replication of this virus take place in the cytoplasm. Like other giant viruses, it affect the host’s nucleus and can take up to 15 hours to start infecting.[21] Although it is found in water, it does not affect humans, it may actually help us by increasing the production of oxygen in aquatic environments.[22] 

Phycodnaviridae

Order Algavirales. The Phycodnaviridae are icosahedral in shape with a double-stranded DNA molecule. Some members of this family can have a linear double-stranded DNA while others have a circular double stranded DNA. The genome has been found to be up to 560 kilobases in length. Up to 50% of the DNA can be represented by guanine or cytosine. This virus is known to infect algae, which means it is found in the ocean.[23]

Pithoviridae

Possibly order Pimascovirales. The Pithoviridae have only two known representatives. These viruses infects amoebas and can survive in low temperatures. For years this virus was believed to be frozen, but due to climate change it has begun to show up again.[24] This is a double stranded DNA virus with its size being 610 kilobases long. The genome is estimated to code for 476 open reading frames. The viron is rod shaped with a length of 1,100 nm long and 500 nm in diameter.[25]

Poxviridae

Order Chitovirales. The Poxviridae have a linear double-stranded DNA molecule that can have a length of up to 230 kilobases. The replication of these viruses takes place in the cytoplasm. Smallpox, cowpox, and other pox viruses belong to this family.[26] 

Mininucleoviridae

Genome maps of the crustacean viruses PaV1, DhV1 and CmV1 (proposed family Mininucleoviridae).[6]

Possibly order Pimascovirales. A new family has been proposed - Mininucleoviridae - for a family of large viruses that replicate in crustacea.[6] Members of this proposed family include Carcinus maenas virus 1 (CmV1),[note 1] Dikerogammarus haemobaphes virus 1 (DhV1),[note 2] and Panulirus argus virus 1 (PaV1).[note 3]

Unclassified taxa

  • Cedratvirus – now under Pithoviridae (Pimascovirales)
  • Choanovirus – part of extended Mimiviridae, a clade distinct from Mimiviridae proper;[27] (Imitervirales)
  • Dinodnavirus – possibly under Asfarviridae (Asfuvirales)
  • Faustovirus – now under Asfarviridae (Asfuvirales)
  • Kaumoebavirus – clusters under Asfarviridae (Asfuvirales)
  • Medusavirus – proposed to be its own family Medusaviridae, possibly close to Mollivirus[28] or basal in Nucleocytoviricota
  • Meelsvirus  – no sequences available
  • Mollivirus – close to Pandoravirus (Algavirales)
  • Namao virus – (together with Faunusvirus sp. from metagenomics) close to Cafeteriavirus; possibly together with other Sturgeon-NCLDVs; (Imitervirales)
  • Orpheovirus – likely under Pithoviridae; sister group to Cedratvirus[29] (Pimascovirales)
  • Pacmanvirus – likely under Asfarviridae (Asfuvirales)
  • Platanovirus – similar to Megavirus[30] or Tupanvirus (Imitervirales)
  • Sissivirus and Misannotatedvirus – (together with Solumnvirus, Solivirus from metagenomics) possibly under Pithoviridae
  • Tupanvirus – possibly under Mimiviridae (Imitervirales)
  • Urceolovirus – possibly under Nucleocytoviricota
  • Usurpativirus and Clandestinovirus – a clade possibly under Phycodnaviridae nearby Chlorovirus (Algavirales)
  • Yasminevirus – close to Klosneuvirus and Bodo saltans virus; (together with Gaeavirus, Homavirus, Barrevirus, Fadolivirus, Dasosvirus, Edafovirus, Terrestrivirus, Harvfovirus, Hyperionvirus from metagenomics) members of Mimiviridae (Imitervirales)

Phylogenetics

The general consensus is that Iridoviridae–Ascoviridae are closely related sister taxa in a clade. Pithovirus, Iridoviridae–Ascoviridae and Marseillevirus form a PIM or MAPI clade (Pimascovirales[2]) in trees built from conserved proteins.[6] The sister clade to PIM/MAPI is a clade made out of Algavirales[2] (Phycodnaviridae, Pandoraviridae), and possibly Imitervirales[2]/Mimiviridae ("P2" thereafter).[31] Poxviridae is consistently treated as a basal branch. Asfarviridae is either a sister group to Poxviridae (building together Pokkesviricetes)[2] or a member of the P2 clade.[32] The ICTV classification, as of 2019, matches the general shape of the tree.

The origin of the NCLDVs may predate that of their eukaryotic hosts, judging from their RNA polymerase structures.[32]

See also

  • Viral eukaryogenesis

Notes

  1. ↑ CmV1 infects Carcinus maenas
  2. ↑ DhV1 infects Dikerogammarus haemobaphes
  3. ↑ PaV1 infects Panulirus argus

References

  1. 1 2 Colson P, De Lamballerie X, Yutin N, Asgari S, Bigot Y, Bideshi DK, Cheng XW, Federici BA, Van Etten JL, Koonin EV, La Scola B, Raoult D (2013). ""Megavirales", a proposed new order for eukaryotic nucleocytoplasmic large DNA viruses". Archives of Virology. 158 (12): 2517–21. doi:10.1007/s00705-013-1768-6. PMC 4066373. PMID 23812617.
  2. 1 2 3 4 5 "Virus Taxonomy: 2019 Release". talk.ictvonline.org. International Committee on Taxonomy of Viruses. Retrieved 25 April 2020.
  3. ↑ Koonin EV, Dolja VV, Krupovic M, Varsani A, Wolf YI, Yutin N, Zerbini M, Kuhn JH (October 2019). "Create a megataxonomic framework, filling all principal taxonomic ranks, for DNA viruses encoding vertical jelly roll-type major capsid proteins". ICTV Proposal (Taxoprop): 2019.003G. doi:10.13140/RG.2.2.14886.47684.
  4. ↑ Colson P, de Lamballerie X, Fournous G, Raoult D (2012). "Reclassification of giant viruses composing a fourth domain of life in the new order Megavirales". Intervirology. 55 (5): 321–332. doi:10.1159/000336562. PMID 22508375.
  5. ↑ Iyer, L. M.; Aravind, L.; Koonin, E. V. (December 2001). "Common Origin of Four Diverse Families of Large Eukaryotic DNA Viruses". Journal of Virology. 75 (23): 11720–34. doi:10.1128/JVI.75.23.11720-11734.2001. PMC 114758. PMID 11689653.
  6. 1 2 3 4 Subramaniam, K (14 January 2020). "A New Family of DNA Viruses Causing Disease in Crustaceans from Diverse Aquatic Biomes". mBio. 11 (1). doi:10.1128/mBio.02938-19. PMC 6960288. PMID 31937645.
  7. ↑ "Ascoviridae—Ascoviridae—dsDNA Viruses—International Committee on Taxonomy of Viruses (ICTV)". International Committee on Taxonomy of Viruses (ICTV). Retrieved 2017-12-07.
  8. ↑ Asgari, Sassan; Bideshi, Dennis K; Bigot, Yves; Federici, Brian A; Cheng, Xiao-Wen (2017). "ICTV Virus Taxonomy Profile: Ascoviridae". The Journal of General Virology. 98 (1): 4–5. doi:10.1099/jgv.0.000677. ISSN 0022-1317. PMC 5370392. PMID 28218573.
  9. ↑ "African swine fever (ASF) | animal disease". Encyclopedia Britannica. Retrieved 2017-12-07.
  10. ↑ "Iridoviridae—Iridoviridae—dsDNA Viruses—International Committee on Taxonomy of Viruses (ICTV)". International Committee on Taxonomy of Viruses (ICTV). Retrieved 2017-12-07.
  11. ↑ Boyer, Mickaël; Yutin, Natalya; Pagnier, Isabelle; Barrassi, Lina; Fournous, Ghislain; Espinosa, Leon; Robert, Catherine; Azza, Saïd; Sun, Siyang (2009-12-22). "Giant Marseillevirus highlights the role of amoebae as a melting pot in emergence of chimeric microorganisms". Proceedings of the National Academy of Sciences of the United States of America. 106 (51): 21848–21853. Bibcode:2009PNAS..10621848B. doi:10.1073/pnas.0911354106. ISSN 0027-8424. PMC 2799887. PMID 20007369.
  12. ↑ Aherfi, Sarah (2014-10-01). "The expanding family Marseilleviridae". Virology. 466–467: 27–37. doi:10.1016/j.virol.2014.07.014. ISSN 0042-6822. PMID 25104553.
  13. ↑ Arslan, Defne; Legendre, Matthieu; Seltzer, Virginie; Abergel, Chantal; Claverie, Jean-Michel (2011-10-18). "Distant Mimivirus relative with a larger genome highlights the fundamental features of Megaviridae". Proceedings of the National Academy of Sciences. 108 (42): 17486–17491. Bibcode:2011PNAS..10817486A. doi:10.1073/pnas.1110889108. ISSN 0027-8424. PMC 3198346. PMID 21987820.
  14. ↑ Schulz, Frederik; Yutin, Natalya; Ivanova, Natalia N.; Ortega, Davi R.; Lee, Tae Kwon; Vierheilig, Julia; Daims, Holger; Horn, Matthias; Wagner, Michael (2017-04-07). "Giant viruses with an expanded complement of translation system components" (PDF). Science. 356 (6333): 82–85. Bibcode:2017Sci...356...82S. doi:10.1126/science.aal4657. ISSN 0036-8075. PMID 28386012. S2CID 206655792., UCPMS ID: 1889607, PDF
  15. ↑ Koonin, EV; Krupovic, M; Yutin, N (2015). "Evolution of double-stranded DNA viruses of eukaryotes: from bacteriophages to transposons to giant viruses". Annals of the New York Academy of Sciences. 1341 (1): 10–24. Bibcode:2015NYASA1341...10K. doi:10.1111/nyas.12728. PMC 4405056. PMID 25727355. Figure 3
  16. ↑ Yutin, Natalya; et al. (2013). "Mimiviridae: clusters of orthologous genes, reconstruction of gene repertoire evolution and proposed expansion of the giant virus family". Virology Journal. 10: 106. doi:10.1186/1743-422X-10-106. PMC 3620924. PMID 23557328.
  17. ↑ Blog of Carolina Reyes, Kenneth Stedman: Are Phaeocystis globosa viruses (OLPG) and Organic Lake phycodnavirus a part of the Phycodnaviridae or Mimiviridae?, on ResearchGate, Jan. 8, 2016
  18. ↑ Maruyama, Fumito; Shoko (2016). "Evolution and Phylogeny of Large DNA Viruses, Mimiviridae and Phycodnaviridae Including Newly Characterized Heterosigma akashiwo Virus". Frontiers in Microbiology. 7: 1942. doi:10.3389/fmicb.2016.01942. PMC 5127864. PMID 27965659.
  19. ↑ Zhang, W; Zhou, J; Liu, T; Yu, Y; Pan, Y; Yan, S; Wang, Y (2015). "Four novel algal virus genomes discovered from Yellowstone Lake metagenomes". Scientific Reports. 5: 15131. Bibcode:2015NatSR...515131Z. doi:10.1038/srep15131. PMC 4602308. PMID 26459929. Figure 6
  20. ↑ Yong, Ed (2013). "Giant viruses open Pandora's box". Nature. doi:10.1038/nature.2013.13410. S2CID 88440241.
  21. ↑ Aherfi, Sarah; Colson, Philippe; La Scola, Bernard; Raoult, Didier (2016-03-22). "Giant Viruses of Amoebas: An Update". Frontiers in Microbiology. 7: 349. doi:10.3389/fmicb.2016.00349. ISSN 1664-302X. PMC 4801854. PMID 27047465.
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  25. ↑ "Pithovirus". viralzone.expasy.org. Retrieved 2017-12-07.
  26. ↑ Moss, Bernard (2013). "Poxvirus DNA Replication". Cold Spring Harbor Perspectives in Biology. 5 (9): a010199. doi:10.1101/cshperspect.a010199. ISSN 1943-0264. PMC 3753712. PMID 23838441.
  27. ↑ Needham, David M.; Yoshizawa, Susumu; Hosaka, Toshiaki; Poirier, Camille; Choi, Chang Jae; Hehenberger, Elisabeth; Irwin, Nicholas A. T.; Wilken, Susanne; Yung, Cheuk-Man; Bachy, Charles; Kurihara, Rika; Nakajima, Yu; Kojima, Keiichi; Kimura-Someya, Tomomi; Leonard, Guy; Malmstrom, Rex R.; Mende, Daniel R.; Olson, Daniel K.; Sudo, Yuki; Sudek, Sebastian; Richards, Thomas A.; DeLong, Edward F.; Keeling, Patrick J.; Santoro, Alyson E.; Shirouzu, Mikako; Iwasaki, Wataru; Worden, Alexandra Z. (8 October 2019). "A distinct lineage of giant viruses brings a rhodopsin photosystem to unicellular marine predators". Proceedings of the National Academy of Sciences. 116 (41): 20574–20583. Bibcode:2019PNAS..11620574N. doi:10.1073/pnas.1907517116. PMC 6789865. PMID 31548428.
  28. ↑ Yoshikawa, Genki; Blanc-Mathieu, Romain; Song, Chihong; Kayama, Yoko; Mochizuki, Tomohiro; Murata, Kazuyoshi; Ogata, Hiroyuki; Takemura, Masaharu (2019). "Medusavirus, a novel large DNA virus discovered from hot spring water". Journal of Virology. 93 (8). doi:10.1128/JVI.02130-18. PMC 6450098. PMID 30728258.
  29. ↑ Andreani, Julien; Khalil, Jacques Y. B.; Baptiste, Emeline; Hasni, Issam; Michelle, Caroline; Raoult, Didier; Levasseur, Anthony; La Scola, Bernard (22 January 2018). "Orpheovirus IHUMI-LCC2: A New Virus among the Giant Viruses". Frontiers in Microbiology. 8: 2643. doi:10.3389/fmicb.2017.02643. PMC 5786535. PMID 29403444.
  30. ↑ "New Giant Virus in Free-Living Amoeba". Wiley Analytical Science. 20 July 2018. doi:10.1002/imaging.6224 (inactive 2021-12-03).{{cite magazine}}: CS1 maint: DOI inactive as of December 2021 (link)
  31. ↑ Bäckström D, Yutin N, Jørgensen SL, Dharamshi J, Homa F, Zaremba-Niedwiedzka K, Spang A, Wolf YI, Koonin EV, Ettema TJ (2019). "Virus genomes from deep sea sediments expand the ocean megavirome and support independent origins of viral gigantism". mBio. 10 (2): e02497-18. doi:10.1128/mBio.02497-18. PMC 6401483. PMID 30837339.PDF
  32. 1 2 Guglielmini, Julien; Woo, Anthony C.; Krupovic, Mart; Forterre, Patrick; Gaia, Morgan (2019-09-10). "Diversification of giant and large eukaryotic dsDNA viruses predated the origin of modern eukaryotes". Proceedings of the National Academy of Sciences. 116 (39): 19585–19592. doi:10.1073/pnas.1912006116. ISSN 0027-8424. PMC 6765235. PMID 31506349.
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