Siplizumab
| Monoclonal antibody | |
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| Type | Whole antibody |
| Source | Humanized (from rat) |
| Target | CD2 |
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Siplizumab (MEDI-507) is a novel monoclonal antibody with a human IgG1, kappa directed to CD2. The agent has shown potent immunomodulatory effects, selectively suppressing the function of T and NK cells, and is currently being tested as a possible treatment for psoriasis and in the prevention of graft-versus-host disease.[1]
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