SHC3
SHC3 (SHC adaptor protein 3) هوَ بروتين يُشَفر بواسطة جين SHC3 في الإنسان.[1][2]
الوظيفة
المراجع
- Nakamura T؛ Sanokawa R؛ Sasaki Y؛ Ayusawa D؛ Oishi M؛ Mori N (نوفمبر 1996)، "N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway"، Oncogene، 13 (6): 1111–21، PMID 8808684.
- "Entrez Gene: SHC3 SHC (Src homology 2 domain containing) transforming protein 3"، مؤرشف من الأصل في 05 ديسمبر 2010.
قراءة متعمقة
- "A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain."، Proc. Natl. Acad. Sci. U.S.A.، 93 (7): 2729–34، 1996، Bibcode:1996PNAS...93.2729O، doi:10.1073/pnas.93.7.2729، PMC 39699، PMID 8610109.
- "A family of Shc related proteins with conserved PTB, CH1 and SH2 regions."، Oncogene، 13 (3): 633–41، 1996، PMID 8760305.
- Menegon A؛ Leoni C؛ Benfenati F؛ Valtorta F (1997)، "Tat protein from HIV-1 activates MAP kinase in granular neurons and glial cells from rat cerebellum."، Biochem. Biophys. Res. Commun.، 238 (3): 800–5، doi:10.1006/bbrc.1997.7393، PMID 9325171.
- "Signal transduction in human hematopoietic cells by vascular endothelial growth factor related protein, a novel ligand for the FLT4 receptor."، Blood، 90 (9): 3507–15، 1997، PMID 9345034.
- Nakamura T؛ Muraoka S؛ Sanokawa R؛ Mori N (1998)، "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling."، J. Biol. Chem.، 273 (12): 6960–7، doi:10.1074/jbc.273.12.6960، PMID 9507002.
- Cook KK؛ Fadool DA (2002)، "Two adaptor proteins differentially modulate the phosphorylation and biophysics of Kv1.3 ion channel by SRC kinase."، J. Biol. Chem.، 277 (15): 13268–80، doi:10.1074/jbc.M108898200، PMC 2779217، PMID 11812778.
- "Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc."، J. Biol. Chem.، 277 (19): 16798–804، 2002، doi:10.1074/jbc.M110286200، PMID 11877420.
- Liu HY؛ Meakin SO (2002)، "ShcB and ShcC activation by the Trk family of receptor tyrosine kinases."، J. Biol. Chem.، 277 (29): 26046–56، doi:10.1074/jbc.M111659200، PMID 12006576.
- "Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines."، Oncogene، 21 (38): 5823–34، 2002، doi:10.1038/sj.onc.1205735، PMID 12185581.
- "The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway."، Mol. Cell. Biol.، 22 (20): 7351–63، 2002، doi:10.1128/MCB.22.20.7351-7363.2002، PMC 139827، PMID 12242309.
- "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules."، Mol. Cell. Biol.، 22 (24): 8721–34، 2003، doi:10.1128/MCB.22.24.8721-8734.2002، PMC 139861، PMID 12446789.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."، Proc. Natl. Acad. Sci. U.S.A.، 99 (26): 16899–903، 2003، Bibcode:2002PNAS...9916899M، doi:10.1073/pnas.242603899، PMC 139241، PMID 12477932.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."، Genome Res.، 14 (10B): 2121–7، 2004، doi:10.1101/gr.2596504، PMC 528928، PMID 15489334.
- "Domain-specific function of ShcC docking protein in neuroblastoma cells."، Oncogene، 24 (19): 3206–15، 2005، doi:10.1038/sj.onc.1208523، PMID 15735675.
- "Shc3 affects human high-grade astrocytomas survival."، Oncogene، 24 (33): 5198–206، 2005، doi:10.1038/sj.onc.1208708، PMID 15870690.
- "RAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumors."، Oncogene، 24 (41): 6303–13، 2005، doi:10.1038/sj.onc.1208776، PMID 15940252.
- "HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway."، Mol. Biol. Cell، 17 (4): 1985–94، 2006، doi:10.1091/mbc.E05-08-0717، PMC 1415297، PMID 16436505.
- "Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence."، Mol. Psychiatry، 12 (5): 462–73، 2007، doi:10.1038/sj.mp.4001933، PMID 17179996.
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