CDKN2B
CDKN2B (Cyclin dependent kinase inhibitor 2B) هوَ بروتين يُشَفر بواسطة جين CDKN2B في الإنسان.[1][2]
الوظيفة
المراجع
- "p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest"، Nature، 371 (6494): 257–61، أكتوبر 1994، doi:10.1038/371257a0، PMID 8078588.
- "Entrez Gene: CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)"، مؤرشف من الأصل في 05 ديسمبر 2010.
قراءة متعمقة
- "Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins"، Oncogene، 11 (8): 1581–8، 1995، PMID 7478582.
- "Genomic structure, expression and mutational analysis of the P15 (MTS2) gene"، Oncogene، 11 (5): 987–91، 1995، PMID 7675459.
- "Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancer"، Cancer Res.، 55 (7): 1448–51، 1995، PMID 7882351.
- "Deletion of p16 and p15 genes in brain tumors"، Cancer Res.، 54 (24): 6353–8، 1994، PMID 7987828.
- "Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function"، Genes Dev.، 8 (24): 2939–52، 1994، doi:10.1101/gad.8.24.2939، PMID 8001816.
- "A cell cycle regulator potentially involved in genesis of many tumor types"، Science، 264 (5157): 436–40، 1994، doi:10.1126/science.8153634، PMID 8153634.
- "The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2"، Genes Dev.، 11 (4): 492–503، 1997، doi:10.1101/gad.11.4.492، PMID 9042862.
- "Transforming growth factor beta stabilizes p15INK4B protein, increases p15INK4B-cdk4 complexes, and inhibits cyclin D1-cdk4 association in human mammary epithelial cells"، Mol. Cell. Biol.، 17 (5): 2458–67، 1997، PMC 232094، PMID 9111314.
- "Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15"، Nature، 387 (6631): 417–22، 1997، doi:10.1038/387417a0، PMID 9163429.
- "Cloning and characterization of p10, an alternatively spliced form of p15 cyclin-dependent kinase inhibitor"، Cancer Res.، 57 (14): 2966–73، 1997، PMID 9230210.
- "Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines"، J. Biol. Chem.، 274 (49): 35053–8، 1999، doi:10.1074/jbc.274.49.35053، PMID 10574984.
- "Tumor suppressor INK4: refinement of p16INK4A structure and determination of p15INK4B structure by comparative modeling and NMR data"، Protein Sci.، 9 (6): 1120–8، 2000، doi:10.1110/ps.9.6.1120، PMC 2144649، PMID 10892805.
- "DNA cloning using in vitro site-specific recombination"، Genome Res.، 10 (11): 1788–95، 2000، doi:10.1101/gr.143000، PMC 310948، PMID 11076863.
- "Repression of p15INK4b expression by Myc through association with Miz-1"، Nat. Cell Biol.، 3 (4): 392–9، 2001، doi:10.1038/35070076، PMID 11283613.
- "Evaluation of alterations in the tumor suppressor genes INK4A and INK4B in human bladder tumors"، Methods Mol. Biol.، 179: 43–59، 2002، doi:10.1385/1-59259-238-4:043، PMID 11692873.
- "Over-expression of CDKIs p15INK4b, p16INK4a and p21CIP1/WAF1 genes mediate growth arrest in human osteosarcoma cell lines"، In Vivo، 15 (5): 443–6، 2002، PMID 11695244.
- "Alterations of INK4a(p16-p14ARF)/INK4b(p15) expression and telomerase activation in meningioma progression"، J. Neurooncol.، 55 (3): 149–58، 2001، doi:10.1023/A:1013863630293، PMID 11859969.
- "Frequent abnormalities of the p15 and p16 genes in mycosis fungoides and sezary syndrome"، J. Invest. Dermatol.، 118 (3): 493–9، 2002، doi:10.1046/j.0022-202x.2001.01682.x، PMID 11874489.
- "Inactivation of p16/CDKN2 and p15/MTS2 is associated with prognosis and response to chemotherapy in ovarian cancer"، Int. J. Cancer، 99 (4): 579–82، 2002، doi:10.1002/ijc.10331، PMID 11992549.
بوابة طب
بوابة علم الأحياء الخلوي والجزيئي
بوابة الكيمياء الحيوية
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