CDKN2C
CDKN2C (Cyclin dependent kinase inhibitor 2C) هوَ بروتين يُشَفر بواسطة جين CDKN2C في الإنسان.[1][2][3]
الوظيفة
المراجع
- "Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer"، Biochem. Biophys. Res. Commun.، 247 (1): 146–53، يوليو 1998، doi:10.1006/bbrc.1998.8497، PMID 9636670.
- "Entrez Gene: CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)"، مؤرشف من الأصل في 05 ديسمبر 2010.
- "Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function"، Genes Dev.، 8 (24): 2939–52، يناير 1995، doi:10.1101/gad.8.24.2939، PMID 8001816.
قراءة متعمقة
- "A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4"، Nature، 366 (6456): 704–7، 1993، doi:10.1038/366704a0، PMID 8259215.
- "Expression of the leukemia-associated gene, p18, in normal and malignant tissues; inactivation of expression in a patient with cleaved B cell lymphoma/leukemia"، Oncogene، 8 (10): 2869–72، 1993، PMID 8397372.
- "Characterization of p18, a component of the lamin B receptor complex and a new integral membrane protein of the avian erythrocyte nuclear envelope"، J. Biol. Chem.، 271 (21): 12617–25، 1996، doi:10.1074/jbc.271.21.12617، PMID 8647873.
- "Biochemical characterization of p16INK4- and p18-containing complexes in human cell lines"، J. Biol. Chem.، 271 (27): 15942–9، 1996، doi:10.1074/jbc.271.27.15942، PMID 8663131.
- "A p18 mutant defective in CDK6 binding in human breast cancer cells"، Cancer Res.، 56 (20): 4586–9، 1996، PMID 8840966.
- "Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations"، Nat. Struct. Biol.، 5 (1): 74–81، 1998، doi:10.1038/nsb0198-74، PMID 9437433.
- "Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule"، Oncogene، 16 (5): 587–96، 1998، doi:10.1038/sj.onc.1201580، PMID 9482104.
- "Analysis of CDKN2A, CDKN2B, CDKN2C, and cyclin Ds gene status in hepatoblastoma"، Hepatology، 27 (4): 989–95، 1998، doi:10.1002/hep.510270414، PMID 9537438.
- "Identification of functional elements of p18INK4C essential for binding and inhibition of cyclin-dependent kinase (CDK) 4 and CDK6"، Cancer Res.، 59 (3): 558–64، 1999، PMID 9973200.
- "Tumor suppressor INK4: determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4A"، Biochemistry، 38 (10): 2930–40، 1999، doi:10.1021/bi982286e، PMID 10074345.
- "Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity"، Oncogene، 18 (9): 1663–76، 1999، doi:10.1038/sj.onc.1202466، PMID 10208428.
- "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags"، Proc. Natl. Acad. Sci. U.S.A.، 97 (7): 3491–6، 2000، doi:10.1073/pnas.97.7.3491، PMC 16267، PMID 10737800.
- "Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade and clinical outcome"، Arch. Pathol. Lab. Med.، 126 (1): 42–8، 2002، doi:10.1043/0003-9985(2002)126<0042:IAOPAP>2.0.CO;2، PMID 11800646.
- "Regulation of the human cyclin-dependent kinase inhibitor p18INK4c by the transcription factors E2F1 and Sp1"، J. Biol. Chem.، 277 (35): 31679–93، 2002، doi:10.1074/jbc.M204554200، PMID 12077144.
- "Evidence of a role for the INK4 family of cyclin-dependent kinase inhibitors in ovarian granulosa cell tumors"، Genes Chromosomes Cancer، 35 (2): 176–81، 2002، doi:10.1002/gcc.10108، PMID 12203782.
- "Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells"، Br. J. Cancer، 88 (8): 1277–80، 2003، doi:10.1038/sj.bjc.6600862، PMC 2747579، PMID 12698196.
- "Silencing of the p18INK4c gene by promoter hypermethylation in Reed-Sternberg cells in Hodgkin lymphomas"، Blood، 103 (6): 2351–7، 2004، doi:10.1182/blood-2003-07-2356، PMID 14645011.
بوابة طب
بوابة الكيمياء الحيوية
بوابة علم الأحياء الخلوي والجزيئي
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