FCER1G

FCER1G
المعرفات
الأسماء المستعارة	FCER1G, FCRG, Fc fragment of IgE receptor Ig, Fc epsilon receptor Ig
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 147139 MGI: MGI:95496 HomoloGene: 3029 GeneCards: 2207
علم الوجود الجيني
الوظيفة الجزيئية	• IgE receptor activity; • IgG binding; • ‏GO:0001948، ‏GO:0016582 ربط بروتيني; • IgE binding; • transmembrane signaling receptor activity; • protein homodimerization activity;
المكونات الخلوية	• مكون تكاملي للغشاء; • غشاء; • غشاء خلوي; • Fc-epsilon receptor I complex; • external side of plasma membrane; • tertiary granule membrane; • ficolin-1-rich granule membrane; • integral component of plasma membrane; • cell surface;
العمليات الحيوية	• mast cell activation; • positive regulation of phagocytosis; • Fc receptor mediated stimulatory signaling pathway; • antigen processing and presentation of exogenous peptide antigen via MHC class II; • positive regulation of interleukin-10 production; • negative regulation of mast cell apoptotic process; • receptor internalization; • positive regulation of type IIa hypersensitivity; • neutrophil activation involved in immune response; • serotonin secretion by platelet; • stimulatory C-type lectin receptor signaling pathway; • تجلط الدم; • cellular response to low-density lipoprotein particle stimulus; • positive regulation of mast cell degranulation; • neutrophil chemotaxis; • antigen processing and presentation of exogenous peptide antigen via MHC class I; • platelet activation; • سبيل إشارات مستقبلات سطح الخلية; • phagocytosis, engulfment; • positive regulation of immune response; • positive regulation of type I hypersensitivity; • defense response to bacterium; • immunoglobulin mediated immune response; • Fc-gamma receptor signaling pathway; • positive regulation of mast cell cytokine production; • positive regulation of interleukin-6 production; • regulation of immune response; • positive regulation of tumor necrosis factor production; • integrin-mediated signaling pathway; • regulation of platelet activation; • protein localization to plasma membrane; • positive regulation of type III hypersensitivity; • T cell differentiation involved in immune response; • leukocyte migration; • ‏GO:0072468 توصيل الإشارة; • مناعة فطرية; • neutrophil degranulation; • protein homooligomerization; • Fc-epsilon receptor signaling pathway; • osteoclast differentiation; • interleukin-2 production; • positive regulation of protein localization to cell surface; • positive regulation of interleukin-4 production; • interleukin-3-mediated signaling pathway; • immune system process;
	المصادر:Amigo / QuickGO
أورثولوج
	P30273
	P20491
	NM_004106
	NM_010185
	NP_004097
	NP_034315
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

FCER1G‏ (Fc fragment of IgE receptor Ig) هوَ بروتين يُشَفر بواسطة جين FCER1G في الإنسان.[1]

المراجع

"Entrez Gene: Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide"، مؤرشف من الأصل في 2 أكتوبر 2016.

قراءة متعمقة

"A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets"، The Journal of Biological Chemistry، 272 (38): 23528–31، سبتمبر 1997، doi:10.1074/jbc.272.38.23528، PMID 9295288.
"Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor"، The Journal of Biological Chemistry، 269 (35): 22427–32، سبتمبر 1994، PMID 8071371.
"Expression feature of CD3, FcεRIγ, and Zap-70 in patients with chronic lymphocytic leukemia"، Hematology، 17 (2): 71–5، مارس 2012، doi:10.1179/102453312X13221316477895، PMID 22664044.
"Association and functional relevance of E237G, a polymorphism of the high-affinity immunoglobulin E-receptor beta chain gene, to airway hyper-responsiveness"، Clinical and Experimental Allergy، 37 (4): 592–8، أبريل 2007، doi:10.1111/j.1365-2222.2007.02680.x، PMID 17430357.
"Alternative expression of TCRζ related genes in patients with chronic myeloid leukemia"، Journal of Hematology & Oncology، 5: 74، ديسمبر 2012، doi:10.1186/1756-8722-5-74، PMC 3544630، PMID 23228155.
"Cooperative regulation of Fc receptor gamma-chain gene expression by multiple transcription factors, including Sp1, GABP, and Elf-1"، The Journal of Biological Chemistry، 283 (22): 15134–41، مايو 2008، doi:10.1074/jbc.M800498200، PMC 3258888، PMID 18378679.
"CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl"، Journal of Immunology، 189 (2): 786–92، يوليو 2012، doi:10.4049/jimmunol.1200887، PMC 3665352، PMID 22706086.
"Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets"، European Journal of Biochemistry، 263 (3): 612–23، أغسطس 1999، doi:10.1046/j.1432-1327.1999.00560.x، PMID 10469124.
"Association between reduced levels of total serum IgE and FcepsilonRI expression in non-releaser basophils"، Immunobiology، 214 (5): 377–83، 2009، doi:10.1016/j.imbio.2008.09.008، PMID 19362683.

بوابة الكيمياء الحيوية
بوابة طب
بوابة علم الأحياء الخلوي والجزيئي

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[entrez-1] "Entrez Gene: Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide"، مؤرشف من الأصل في 2 أكتوبر 2016.

التصنيفات الطبية	OMIM ID: 147139
المعرفات الخارجية	Ensembl Transcript ID: ENST00000490414, ENST00000289902, ENST00000367992