WNT3A

WNT3A
المعرفات
الأسماء المستعارة	WNT3A, Wnt family member 3A
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 606359 MGI: MGI:98956 HomoloGene: 22528 GeneCards: 89780
علم الوجود الجيني
الوظيفة الجزيئية	• protein domain specific binding; • signaling receptor binding; • co-receptor binding; • ‏GO:0005110 frizzled binding; • ‏GO:0001948، ‏GO:0016582 ربط بروتيني; • ‏GO:0001105 transcription coactivator activity; • receptor ligand activity;
المكونات الخلوية	• endocytic vesicle membrane; • endoplasmic reticulum lumen; • منطقة خارج الخلية; • cell surface; • حويصلة خارج خلوية; • Wnt-Frizzled-LRP5/6 complex; • early endosome membrane; • غشاء خلوي; • تجويف غولجي; • presynapse; • خارج خلوي; • تشابك عصبي; • glutamatergic synapse;
العمليات الحيوية	• تكون الجسيدات; • cellular response to retinoic acid; • تكون الدم; • positive regulation of protein phosphorylation; • Wnt signaling pathway involved in forebrain neuroblast division; • positive regulation of skeletal muscle tissue development; • positive regulation of receptor internalization; • axis elongation involved in somitogenesis; • positive regulation of collateral sprouting in absence of injury; • تطور الثدي; • platelet activation; • heart looping; • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; • positive regulation of protein localization to plasma membrane; • cardiac muscle cell fate commitment; • mesoderm development; • cell proliferation in forebrain; • positive regulation of mesodermal cell fate specification; • negative regulation of fat cell differentiation; • canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment; • regulation of microtubule cytoskeleton organization; • negative regulation of dopaminergic neuron differentiation; • cell proliferation in midbrain; • in utero embryonic development; • negative regulation of axon extension involved in axon guidance; • positive regulation of peptidyl-serine phosphorylation; • ‏GO:0060469، ‏GO:0009371 positive regulation of transcription, DNA-templated; • regulation of axonogenesis; • positive regulation of B cell proliferation; • post-anal tail morphogenesis; • positive regulation of cardiac muscle cell differentiation; • negative regulation of neuron projection development; • paraxial mesodermal cell fate commitment; • negative regulation of neurogenesis; • positive regulation of protein tyrosine kinase activity; • positive regulation of DNA-binding transcription factor activity; • extracellular matrix organization; • positive regulation of neural precursor cell proliferation; • synaptic vesicle recycling; • osteoblast differentiation; • skeletal muscle cell differentiation; • COP9 signalosome assembly; • dorsal/ventral neural tube patterning; • positive regulation of protein binding; • platelet aggregation; • midbrain development; • positive regulation of protein kinase activity; • positive regulation of cell-cell adhesion mediated by cadherin; • positive regulation of hepatocyte proliferation; • تخلق النسيج العصبي; • spinal cord association neuron differentiation; • axonogenesis; • ‏GO:0032737 positive regulation of cytokine production; • positive regulation of dermatome development; • somatic stem cell division; • positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation; • axon guidance; • نمو متعدد الخلايا; • determination of left/right symmetry; • inner ear morphogenesis; • ضبط زيادي للتكاثر الخلوي; • regulation of cell differentiation; • hippocampus development; • negative regulation of heart induction by canonical Wnt signaling pathway; • ‏GO:0003257، ‏GO:0010735، ‏GO:1901228، ‏GO:1900622، ‏GO:1904488 ضبط زيادي للنسخ انطلاقا من محفز بوليميراز الرنا الثاني; • نقل شاردة الكالسيوم; • Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; • beta-catenin destruction complex disassembly; • neuron differentiation; • بروتين دبيلو.أن.تي; • positive regulation of canonical Wnt signaling pathway; • ‏GO:1901313 positive regulation of gene expression; • calcium ion transmembrane transport via low voltage-gated calcium channel; • presynapse assembly; • negative regulation of neuron death; • positive regulation of core promoter binding; • regulation of RNA biosynthetic process; • regulation of signaling receptor activity; • cell population proliferation; • canonical Wnt signaling pathway; • secondary palate development; • cell fate commitment; • modulation of chemical synaptic transmission; • ‏GO:1904739 regulation of synapse organization; • postsynapse to nucleus signaling pathway; • regulation of presynapse assembly;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	المزيد من بيانات التعبير المرجعية
أورثولوج
	P56704
	P27467
	NM_033131
	NM_009522
	‏XP_011542621 NP_149122، ‏XP_011542621
	NP_033548
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

WNT3A‏ (Wnt family member 3A) هوَ بروتين يُشَفر بواسطة جين WNT3A في الإنسان.[1][2][3]

المراجع

"Molecular cloning and characterization of WNT3A and WNT14 clustered in human chromosome 1q42 region"، Biochem Biophys Res Commun، 284 (5): 1168–75، يونيو 2001، doi:10.1006/bbrc.2001.5105، PMID 11414706.
Kennell, Jennifer A.؛ MacDougald, Ormond A. (24 يونيو 2005)، "Wnt Signaling Inhibits Adipogenesis through β-Catenin-dependent and -independent Mechanisms"، Journal of Biological Chemistry، 280 (25): 24004–24010، doi:10.1074/jbc.M501080200، PMID 15849360، مؤرشف من الأصل في 12 مايو 2019.
"Entrez Gene: WNT3A wingless-type MMTV integration site family, member 3A"، مؤرشف من الأصل في 05 ديسمبر 2010.

قراءة متعمقة

"Wnt family proteins are secreted and associated with the cell surface."، Mol. Biol. Cell، 4 (12): 1267–75، 1994، doi:10.1091/mbc.4.12.1267، PMC 275763، PMID 8167409.
"Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue."، Cancer Res.، 54 (10): 2615–21، 1994، PMID 8168088.
"Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response."، Oncogene، 18 (44): 5959–66، 1999، doi:10.1038/sj.onc.1202985، PMID 10557084.
"The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family."، Eur. J. Biochem.، 267 (13): 4300–11، 2000، doi:10.1046/j.1432-1033.2000.01478.x، PMID 10866835.
Katoh M (2002)، "Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45."، Int. J. Oncol.، 20 (2): 373–7، doi:10.3892/ijo.20.2.373، PMID 11788904.
Katoh M (2002)، "Molecular cloning and expression of mouse Wnt14, and structural comparison between mouse Wnt14-Wnt3a gene cluster and human WNT14-WNT3A gene cluster."، Int. J. Mol. Med.، 9 (3): 221–7، doi:10.3892/ijmm.9.3.221، PMID 11836627.
"Wnt-3A/beta-catenin signaling induces transcription from the LEF-1 promoter."، J. Biol. Chem.، 277 (36): 33398–410، 2002، doi:10.1074/jbc.M107977200، PMID 12052822.
"Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95."، FEBS Lett.، 521 (1–3): 185–9، 2002، doi:10.1016/S0014-5793(02)02831-4، PMID 12067714.
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."، Proc. Natl. Acad. Sci. U.S.A.، 99 (26): 16899–903، 2003، doi:10.1073/pnas.242603899، PMC 139241، PMID 12477932.
"Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin."، J. Biol. Chem.، 278 (16): 14066–73، 2003، doi:10.1074/jbc.M213265200، PMID 12556519.
"Wnt signaling in B-cell neoplasia."، Oncogene، 22 (10): 1536–45، 2003، doi:10.1038/sj.onc.1206239، PMID 12629517.
"Regulation of the Wnt signaling pathway by disabled-2 (Dab2)."، EMBO J.، 22 (12): 3084–94، 2003، doi:10.1093/emboj/cdg286، PMC 162138، PMID 12805222.
"A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor."، Mol. Cell. Biol.، 23 (16): 5825–35، 2003، doi:10.1128/MCB.23.16.5825-5835.2003، PMC 166321، PMID 12897152.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."، Nat. Genet.، 36 (1): 40–5، 2004، doi:10.1038/ng1285، PMID 14702039.
"Regulation of casein kinase I epsilon activity by Wnt signaling."، J. Biol. Chem.، 279 (13): 13011–7، 2004، doi:10.1074/jbc.M304682200، PMID 14722104.
"The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway."، J. Biol. Chem.، 279 (17): 17535–42، 2004، doi:10.1074/jbc.M311292200، PMID 14739301.
"Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth."، Cell، 119 (1): 97–108، 2004، doi:10.1016/j.cell.2004.09.019، PMID 15454084.
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."، Genome Res.، 14 (10B): 2121–7، 2004، doi:10.1101/gr.2596504، PMC 528928، PMID 15489334.
"Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth."، J. Biol. Chem.، 280 (50): 41201–6، 2006، doi:10.1074/jbc.M507004200، PMID 16227623.
"Activation of intracellular calcium by multiple Wnt ligands and translocation of ß-catenin into the nucleus: a convergent model of Wnt/Ca2+ and Wnt/ß-catenin pathways"، J. Biol. Chem.، 288 (50): 35651–35659، 2013، doi:10.1074/jbc.M112.437913، PMC 3861617، PMID 24158438.

بوابة علم الأحياء الخلوي والجزيئي
بوابة طب
بوابة الكيمياء الحيوية

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[1] "Molecular cloning and characterization of WNT3A and WNT14 clustered in human chromosome 1q42 region"، Biochem Biophys Res Commun، 284 (5): 1168–75، يونيو 2001، doi:10.1006/bbrc.2001.5105، PMID 11414706.

[2] Kennell, Jennifer A.؛ MacDougald, Ormond A. (24 يونيو 2005)، "Wnt Signaling Inhibits Adipogenesis through β-Catenin-dependent and -independent Mechanisms"، Journal of Biological Chemistry، 280 (25): 24004–24010، doi:10.1074/jbc.M501080200، PMID 15849360، مؤرشف من الأصل في 12 مايو 2019.

[3] "Entrez Gene: WNT3A wingless-type MMTV integration site family, member 3A"، مؤرشف من الأصل في 05 ديسمبر 2010.

التصنيفات الطبية	OMIM ID: 606359
المعرفات الخارجية	Ensembl Transcript ID: ENST00000284523