CLCA1
CLCA1 (Chloride channel accessory 1) هوَ بروتين يُشَفر بواسطة جين CLCA1 في الإنسان.[1][2]
الوظيفة
المراجع
- <ref name="entrez">"Entrez Gene: CLCA1 chloride channel, calcium activated, family member 1"، مؤرشف من الأصل في 05 ديسمبر 2010.
- "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels"، Proteins، 63 (3): 424–39، 2006، doi:10.1002/prot.20887، PMID 16470849.
قراءة متعمقة
- "Anion transport in heart"، Physiol. Rev.، 80 (1): 31–81، 2000، PMID 10617765.
- "Molecular characteristics and functional diversity of CLCA family members"، Clin. Exp. Pharmacol. Physiol.، 27 (11): 901–5، 2001، doi:10.1046/j.1440-1681.2000.03358.x، PMID 11071307.
- "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea"، FEBS Lett.، 455 (3): 295–301، 1999، doi:10.1016/S0014-5793(99)00891-1، PMID 10437792.
- "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags"، Proc. Natl. Acad. Sci. U.S.A.، 97 (7): 3491–6، 2000، doi:10.1073/pnas.97.7.3491، PMC 16267، PMID 10737800.
- "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation"، Proc. Natl. Acad. Sci. U.S.A.، 97 (9): 4832–7، 2000، doi:10.1073/pnas.090521697، PMC 18318، PMID 10758170.
- "A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma"، J. Allergy Clin. Immunol.، 109 (2): 246–50، 2002، doi:10.1067/mai.2002.121555، PMID 11842292.
- "The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1"، J. Biol. Chem.، 277 (25): 22119–22، 2002، doi:10.1074/jbc.C200215200، PMID 11994272.
- "Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth"، J. Biol. Chem.، 277 (37): 34391–400، 2002، doi:10.1074/jbc.M205307200، PMID 12110680.
- "pCLCA1 becomes a cAMP-dependent chloride conductance mediator in Caco-2 cells"، Biochem. Biophys. Res. Commun.، 298 (4): 531–6، 2002، doi:10.1016/S0006-291X(02)02498-1، PMID 12408984.
- "A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction"، Novartis Found. Symp.، 248: 150–65, discussion 165–70, 277–82، 2003، doi:10.1002/0470860790.ch10، PMID 12568493.
- "The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis"، J. Biol. Chem.، 278 (49): 49406–16، 2004، doi:10.1074/jbc.M309086200، PMID 14512419.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs"، Nat. Genet.، 36 (1): 40–5، 2004، doi:10.1038/ng1285، PMID 14702039.
- "CLCA1 gene polymorphisms in chronic obstructive pulmonary disease"، J. Med. Genet.، 41 (3): e27، 2004، doi:10.1136/jmg.2003.012484، PMC 1735703، PMID 14985398.
- "Association of the hCLCA1 gene with childhood and adult asthma"، Genes Immun.، 5 (7): 540–7، 2005، doi:10.1038/sj.gene.6364124، PMID 15318163.
- "The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis"، Hum. Genet.، 115 (6): 483–91، 2005، doi:10.1007/s00439-004-1190-y، PMID 15490240.
- "hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels"، J. Biol. Chem.، 280 (29): 27205–12، 2005، doi:10.1074/jbc.M504654200، PMID 15919655.
- "Cloning and expression of Ca2+-activated chloride channel from rat brain"، Biochem. Biophys. Res. Commun.، 334 (2): 569–76، 2005، doi:10.1016/j.bbrc.2005.06.122، PMID 16023076.
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