HES5

HES5
المعرفات
الأسماء المستعارة	HES5, bHLHb38, hes family bHLH transcription factor 5
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 607348 MGI: MGI:104876 HomoloGene: 7755 GeneCards: 388585
علم الوجود الجيني
الوظيفة الجزيئية	• ربط دي إن إي; • protein dimerization activity; • transcription factor binding; • chromatin binding; • ‏GO:0001078، ‏GO:0001214، ‏GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • double-stranded DNA binding; • ‏GO:0001200، ‏GO:0001133، ‏GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • ‏GO:0001106 transcription corepressor activity; • sequence-specific DNA binding; • sequence-specific double-stranded DNA binding;
المكونات الخلوية	• بلازم نووي; • نواة; • مكون خلوي;
العمليات الحيوية	• Notch signaling pathway; • auditory receptor cell fate determination; • establishment of epithelial cell polarity; • تمايز خلوي; • negative regulation of astrocyte differentiation; • regulation of inner ear auditory receptor cell differentiation; • ‏GO:0009373 ضبط نسخ الدنا; • negative regulation of neuron differentiation; • inner ear receptor cell stereocilium organization; • comma-shaped body morphogenesis; • metanephric nephron tubule morphogenesis; • chondrocyte differentiation; • central nervous system myelination; • ‏GO:1901227 negative regulation of transcription by RNA polymerase II; • cell maturation; • negative regulation of forebrain neuron differentiation; • نسخ الدنا; • نماء عصبي; • negative regulation of stem cell differentiation; • neuronal stem cell population maintenance; • ‏GO:0060469، ‏GO:0009371 positive regulation of transcription, DNA-templated; • نمو متعدد الخلايا; • glial cell fate commitment; • telencephalon development; • brain development; • inner ear auditory receptor cell differentiation; • التصاق الخلايا; • astrocyte differentiation; • تَكوّن الغُضروف; • forebrain radial glial cell differentiation; • regulation of myelination; • negative regulation of oligodendrocyte differentiation; • S-shaped body morphogenesis; • neural tube development; • neuron differentiation; • ضبط زيادي للتكاثر الخلوي; • positive regulation of BMP signaling pathway; • negative regulation of pro-B cell differentiation; • regulation of cell differentiation; • smoothened signaling pathway; • oligodendrocyte development; • camera-type eye development; • specification of loop of Henle identity; • regulation of epithelial cell proliferation; • ‏GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of inner ear receptor cell differentiation; • regulation of neurogenesis; • positive regulation of receptor signaling pathway via JAK-STAT; • positive regulation of Notch signaling pathway; • ‏GO:0003257، ‏GO:0010735، ‏GO:1901228، ‏GO:1900622، ‏GO:1904488 ضبط زيادي للنسخ انطلاقا من محفز بوليميراز الرنا الثاني; • positive regulation of smooth muscle cell proliferation; • positive regulation of tyrosine phosphorylation of STAT protein; • ‏GO:0034622 protein-containing complex assembly; • تكون الجسيدات; • central nervous system development; • نقل شاردة الكالسيوم; • negative regulation of inner ear auditory receptor cell differentiation;
	المصادر:Amigo / QuickGO
أورثولوج
	Q5TA89
	P70120
	‏XM_005244751 NM_001010926، ‏XM_005244751
	‏XM_006538562، ‏NM_001370755 NM_010419، ‏XM_006538562، ‏NM_001370755
	‏XP_005244808 NP_001010926، ‏XP_005244808
	‏XP_006538625، ‏NP_001357684 NP_034549، ‏XP_006538625، ‏NP_001357684
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

HES5‏ (Hes family bHLH transcription factor 5) هوَ بروتين يُشَفر بواسطة جين HES5 في الإنسان.[1][2][3][4][5]

الوظيفة

المراجع

"Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element"، J Biol Chem، 270 (3): 1342–9، فبراير 1995، doi:10.1074/jbc.270.3.1342، PMID 7836401.
"Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation"، Development، 131 (22): 5539–50، نوفمبر 2004، doi:10.1242/dev.01436، PMID 15496443.
"Expression of differentiation associated protein Hes1 and Hes5 in cervical squamous carcinoma and its precursors"، Int. J. Gynecol. Cancer، 17 (6): 1293–9، 2007، doi:10.1111/j.1525-1438.2007.00930.x، PMID 17388915.
"Entrez Gene: HES5 hairy and enhancer of split 5 (Drosophila)"، مؤرشف من الأصل في 05 ديسمبر 2010.
"Notch and HES5 are regulated during human cartilage differentiation"، Cell Tissue Res.، 327 (3): 539–51، مارس 2007، doi:10.1007/s00441-006-0307-0، PMID 17093926.

قراءة متعمقة

"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences."، Proc. Natl. Acad. Sci. U.S.A.، 99 (26): 16899–903، 2003، doi:10.1073/pnas.242603899، PMC 139241، PMID 12477932.
"Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway."، Development، 131 (4): 903–13، 2004، doi:10.1242/dev.00982، PMID 14757642.
"Helt, a novel basic-helix-loop-helix transcriptional repressor expressed in the developing central nervous system."، J. Biol. Chem.، 279 (16): 16356–67، 2004، doi:10.1074/jbc.M311740200، PMID 14764602.
"Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling."، Nat. Cell Biol.، 6 (6): 547–54، 2004، doi:10.1038/ncb1138، PMID 15156153.
"Identification and characterization of human HES2, HES3, and HES5 genes in silico."، Int. J. Oncol.، 25 (2): 529–34، 2005، doi:10.3892/ijo.25.2.529، PMID 15254753.
"Visualization of embryonic neural stem cells using Hes promoters in transgenic mice."، Mol. Cell. Neurosci.، 31 (1): 109–22، 2006، doi:10.1016/j.mcn.2005.09.006، PMID 16214363.
"Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability."، J. Biol. Chem.، 281 (8): 5106–19، 2006، doi:10.1074/jbc.M506108200، PMID 16365048.
"The DNA sequence and biological annotation of human chromosome 1."، Nature، 441 (7091): 315–21، 2006، doi:10.1038/nature04727، PMID 16710414.
"Differentiation of human mesenchymal stem cells and articular chondrocytes: analysis of chondrogenic potential and expression pattern of differentiation-related transcription factors."، J. Orthop. Res.، 25 (2): 152–63، 2007، doi:10.1002/jor.20287، PMID 17072841.
"Notch and HES5 are regulated during human cartilage differentiation."، Cell Tissue Res.، 327 (3): 539–51، 2007، doi:10.1007/s00441-006-0307-0، PMID 17093926.

بوابة طب
بوابة الكيمياء الحيوية
بوابة علم الأحياء الخلوي والجزيئي

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[pmid7836401-1] "Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element"، J Biol Chem، 270 (3): 1342–9، فبراير 1995، doi:10.1074/jbc.270.3.1342، PMID 7836401.

[pmid15496443-2] "Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation"، Development، 131 (22): 5539–50، نوفمبر 2004، doi:10.1242/dev.01436، PMID 15496443.

[pmid17388915-3] "Expression of differentiation associated protein Hes1 and Hes5 in cervical squamous carcinoma and its precursors"، Int. J. Gynecol. Cancer، 17 (6): 1293–9، 2007، doi:10.1111/j.1525-1438.2007.00930.x، PMID 17388915.

[entrez-4] "Entrez Gene: HES5 hairy and enhancer of split 5 (Drosophila)"، مؤرشف من الأصل في 05 ديسمبر 2010.

[pmid17093926-5] "Notch and HES5 are regulated during human cartilage differentiation"، Cell Tissue Res.، 327 (3): 539–51، مارس 2007، doi:10.1007/s00441-006-0307-0، PMID 17093926.

التصنيفات الطبية	OMIM ID: 607348
المعرفات الخارجية	Ensembl Transcript ID: ENST00000378453, ENST00000627397, ENST00000612705