PEA15
PEA15 (Proliferation and apoptosis adaptor protein 15) هوَ بروتين يُشَفر بواسطة جين PEA15 في الإنسان.[1][1][2][3]
المراجع
- "Entrez Gene: PEA15 phosphoprotein enriched in astrocytes 15"، مؤرشف من الأصل في 05 ديسمبر 2010.
- "Assignment of HMAT1, the human homolog of the murine mammary transforming gene (MAT1) associated with tumorigenesis, to 1q21.1, a region frequently gained in human breast cancers"، Genomics، 42 (3): 540–2، سبتمبر 1997، doi:10.1006/geno.1997.4768، PMID 9205133.
- "The PEA-15 protein regulates autophagy via activation of JNK"، J. Biol. Chem.، 285 (28): 21644–54، يوليو 2010، doi:10.1074/jbc.M109.096628، PMC 2898427، PMID 20452983، مؤرشف من الأصل في 07 ديسمبر 2019.
قراءة متعمقة
- "Characterization of PEA-15, a major substrate for protein kinase C in astrocytes"، J. Biol. Chem.، 268 (8): 5911–20، 1993، PMID 8449955.
- "The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs conserved on their full length in mouse and human"، J. Biol. Chem.، 271 (25): 14800–6، 1996، doi:10.1074/jbc.271.25.14800، PMID 8662970.
- "PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus"، EMBO J.، 17 (14): 3858–66، 1998، doi:10.1093/emboj/17.14.3858، PMC 1170721، PMID 9670003.
- "Endothelin induces a calcium-dependent phosphorylation of PEA-15 in intact astrocytes: identification of Ser104 and Ser116 phosphorylated, respectively, by protein kinase C and calcium/calmodulin kinase II in vitro"، J. Neurochem.، 71 (3): 1307–14، 1998، doi:10.1046/j.1471-4159.1998.71031307.x، PMID 9721757.
- "PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis"، Oncogene، 18 (31): 4409–15، 1999، doi:10.1038/sj.onc.1202831، PMID 10442631.
- "Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis"، J. Neurosci.، 19 (19): 8244–51، 1999، PMID 10493725.
- "Molecular characterization of the human PEA15 gene on 1q21-q22 and association with type 2 diabetes mellitus in Pima Indians"، Gene، 241 (1): 143–8، 2000، doi:10.1016/S0378-1119(99)00455-2، PMID 10607908.
- "Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them"، J. Biol. Chem.، 275 (45): 35224–32، 2001، doi:10.1074/jbc.M003329200، PMID 10926929.
- "PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase"، Dev. Cell، 1 (2): 239–50، 2001، doi:10.1016/S1534-5807(01)00035-1، PMID 11702783.
- "Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic function"، J. Biol. Chem.، 277 (13): 11013–8، 2002، doi:10.1074/jbc.M110934200، PMID 11790785.
- "Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells"، J. Biol. Chem.، 277 (28): 25020–5، 2002، doi:10.1074/jbc.M202946200، PMID 11976344.
- "RSK2 activity is regulated by its interaction with PEA-15"، J. Biol. Chem.، 278 (34): 32367–72، 2003، doi:10.1074/jbc.M303988200، PMID 12796492.
- "Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action"، Mol. Cell. Biol.، 23 (13): 4511–21، 2003، doi:10.1128/MCB.23.13.4511-4521.2003، PMC 164852، PMID 12808093.
- "Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15"، J. Biol. Chem.، 279 (45): 46566–72، 2004، doi:10.1074/jbc.M406317200، PMID 15328349.
- "PEA-15 is inhibited by adenovirus E1A and plays a role in ERK nuclear export and Ras-induced senescence"، J. Biol. Chem.، 279 (45): 46802–9، 2004، doi:10.1074/jbc.M403893200، PMID 15331596.
- "Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD"، Biochem. J.، 390 (Pt 3): 729–35، 2006، doi:10.1042/BJ20050378، PMC 1199667، PMID 15916534.
بوابة علم الأحياء الخلوي والجزيئي
بوابة الكيمياء الحيوية
بوابة طب
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