NFATC1

Nuclear factor of activated T-cells, cytoplasmic 1 is a protein that in humans is encoded by the NFATC1 gene.[5]

NFATC1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNFATC1, NF-ATC, NFAT2, NFATc, NF-ATc1.2, nuclear factor of activated T-cells 1, nuclear factor of activated T cells 1
External IDsOMIM: 600489 MGI: 102469 HomoloGene: 32336 GeneCards: NFATC1
Orthologs
SpeciesHumanMouse
Entrez

4772

18018

Ensembl

ENSG00000131196

ENSMUSG00000033016

UniProt

O95644

O88942

RefSeq (mRNA)
RefSeq (protein)

n/a

Location (UCSC)Chr 18: 79.4 – 79.53 MbChr 18: 80.65 – 80.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as ciclosporin. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.[6]

Interactions

NFATC1 has been shown to interact with PIM1.[7]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000131196 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033016 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Northrop JP, Ho SN, Chen L, Thomas DJ, Timmerman LA, Nolan GP, Admon A, Crabtree GR (Jun 1994). "NF-AT components define a family of transcription factors targeted in T-cell activation". Nature. 369 (6480): 497–502. Bibcode:1994Natur.369..497N. doi:10.1038/369497a0. PMID 8202141. S2CID 9920546.
  6. "Entrez Gene: NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1".
  7. Rainio EM, Sandholm J, Koskinen PJ (Feb 2002). "Cutting edge: Transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase". Journal of Immunology. 168 (4): 1524–7. doi:10.4049/jimmunol.168.4.1524. PMID 11823475.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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